Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KIF18B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Gene profile: KIF18B, a kinesin motor protein involved in intracellular transport and neurodegeneration
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| Gene Symbol | KIF18B |
| Full Name | Kinesin Family Member 18B |
| Chromosome | 17q21.31 |
| Protein Family | Kinesin-8 family |
| Function | encodes a protein of 898 amino acids belonging to the kinesin-8 family, characterized by long coiled-coil domains and a conserved motor domain at the N-terminus. |
| Primary Expression | Brain (neurons), mitotic cells |
| Molecular Weight | 110 kDa |
| Amino Acids | 898 aa |
| Exons | 22 |
| UniProt ID | Q86Y56 |
| NCBI Gene ID | 146909 |
| GeneCards | KIF18B |
| Human Protein Atlas | KIF18B |
| N-terminal motor domain (1-400 aa) | Contains the microtubule-binding site and ATPase activity |
| Coiled-coil region (400-700 aa) | Mediates dimerization and cargo binding |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KIF18B["KIF18B"]
neurodegeneration["neurodegeneration"]
KIF18B -->|"implicated_in"| neurodegeneration
style KIF18B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KIF18B in their description or question text
No additional research found