gene

KCNA7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNA7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

0Outgoing

1Incoming

0Experiments

0Debates

Summary

KCNA7 encodes a voltage-gated potassium channel subunit essential for neuronal repolarization, neurotransmitter release, and cellular excitability. Associated with cardiac arrhythmias and neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	KCNA7
Full Name	Potassium Voltage-Gated Channel Subfamily A Member 7
Aliases	Page for KCNA7 Protein
Chromosome	19q13.3
Primary Expression	Brain (hippocampus, cortex), heart, skeletal muscle
Amino Acids	511 aa
Exons	7
UniProt ID	Q9NSC1
NCBI Gene ID	3743
GeneCards	KCNA7
Human Protein Atlas	KCNA7
S1-S4 domains	Form the voltage-sensing module
S5-S6 domains	Form the pore module and selectivity filter
N-terminus	Contains the tetramerization domain (T1) responsible for subunit assembly
C-terminus	Contains regulatory domains and interaction sites
Associated Diseases	neurodegeneration
KG Connections	1 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNA7 — AlphaFold Q9NSC1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KCNA7 Gene - Potassium Voltage-Gated Channel Subfamily A Member 7

gene · 2235 words

→

KCNA7 Protein - Kv1.7 Potassium Channel

protein · 817 words

→

Pathway Diagram

flowchart TD
    N0["KCNA7"]
    N1["BMP-2"]
    N1 -->|"upregulates"| N0
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 protein

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
BMP-2	upregulates	protein	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNA7 in their description or question text

No additional research found