Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Insulin/IGF metabolic signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Metabolic Switch Targeting for A1→A2 Repolarization | 0.726 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
| Metabolic Circuit Breaker via Lipid Droplet Modulation | 0.709 | neurodegeneration | Microglia-astrocyte crosstalk amplificat |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.729
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.741
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | completed | $100,000 |
| Proposed experiment from debate on Microglia activate astrocytes via I | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | completed | $80,000 |
| Metabolic Pathway-Targeted Therapy in ALS | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| GLP-1 Agonist Responder Prediction Study — Precision Medicine for Neur | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Metabolic Syndrome-Parkinson's Disease Axis Clinical Trial | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Cytochrome Therapeutics | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Peroxisomal Dysfunction Validation in Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Peroxisome Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Meta [PMID:41387352] | Pesce NA, Seminara G, Giarrusso G, Tomas | Adv Biol (Weinh) | 2026 | 1 |
| Glucose Metabolic Reprogramming in Microglia: Implications for Neurodegenerative [PMID:39987285] | Fang M, Zhou Y, He K, Lu Y, Tao F, Huang | Mol Neurobiol | 2025 | 1 |
| Hexokinase 2-mediated metabolic stress and inflammation burden of liver macropha [PMID:40014451] | Li J, Chen X, Song S, Jiang W, Geng T, W | Cell Rep | 2025 | 1 |
| Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet-mitochondria [PMID:38773347] | Meng Y, Guo D, Lin L, Zhao H, Xu W, Luo | Nat Metab | 2024 | 1 |
| The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer. [PMID:38904014] | Fontana F, Giannitti G, Marchesi S, Limo | Int J Biol Sci | 2024 | 1 |
| Lipid accumulation drives cellular senescence in dopaminergic neurons. [PMID:39033779] | Russo T, Riessland M | Aging (Albany NY) | 2024 | 1 |
| Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regu [PMID:37494933] | Roberts MA, Deol KK, Mathiowetz AJ, Lang | Dev Cell | 2023 | 1 |
| Comprehensive single-cell transcriptional profiling defines shared and unique ep [PMID:36265491] | Li H, Dixon EE, Wu H, Humphreys BD | Cell Metab | 2022 | 1 |
| Metabolic phenotype of bladder cancer. [PMID:26975021] | Massari F, Ciccarese C, Santoni M, Iacov | Cancer Treat Rev | 2016 | 1 |
| Novel mechanisms of dietary folic acid in improving hepatopancreas health of gra [PMID:41871815] | Wang Y, Feng L, Dan Jiang W, Wu P, Liu Y | The Journal of nutritional bio | 2026 | 0 |
| African swine fever virus hijacks lipolysis induced by chaperone-mediated autoph [PMID:41801037] | ["Yang X", "Xiong X", "Liu H", "Wen X", | mBio | 2026 | 0 |
| Carotid plaque macrophage burden and inflammatory lipid-associated macrophage ma [PMID:41758068] | ["Prange K", "Bel-Bordes G", "Depuydt M" | European heart journal | 2026 | 0 |
| Lipophagy fuels phosphatidylcholine synthesis for Newcastle disease virus replic [PMID:41810751] | ["Yang M", "Chen J", "Su X", "Kan X", "T | Autophagy | 2026 | 0 |
| Epithelial-Mesenchymal Transition Shapes the Lipotoxic Response of Colon Cancer [PMID:41831570] | Vari F, Serra I, Bisconti E, Stanca E, R | Molecular & cellular proteomic | 2026 | 0 |
| Serum Perilipin-2 as a Novel Biomarker for Obstructive Sleep Apnea: Association [PMID:41827192] | Sagcan G, Uzun H | Journal of clinical medicine | 2026 | 0 |
| Aryl hydrocarbon receptor impairs HK2-controlled flux of the hexosamine biosynth [PMID:40582563] | Li S, Zhu J, Song J, Yang L, Gong Y et a | J Adv Res | 2026 | 0 |
| PCDHGC3 silencing promotes clear cell renal cell carcinoma metastasis via mTOR/H [PMID:41888110] | Celada L, Cubiella T, San-Juan-Guardado | Cell death & disease | 2026 | 0 |
| HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis [PMID:41023273] | Mitchell CD, Morris CA, Wild M, Cunningh | Acta Pharmacol Sin | 2026 | 0 |
| Hypoxia-Induced Histone Lactylation Promotes Ferroptosis in Cardiomyocytes via t [PMID:41229334] | Zhu XH, Hou JW, Lv ZY, Sun MH, Zhang XY | Kaohsiung J Med Sci | 2026 | 0 |
| Granzyme B knockdown inhibits NLRP3-mediated pyroptosis and the JAK2/STAT3 signa [PMID:41447776] | Wang M, Chen D, Zhang D, Han H, Xie M et | Tissue Cell | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.95 · 2026-04-10
closed · Rounds: 4 · Score: 0.90 · 2026-04-06
Hypotheses and analyses mentioning Insulin/IGF metabolic signaling in their description or question text
No additional research found