gene

ITM2B

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about ITM2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

ITM2B — Integral Membrane Protein 2B

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🧬 Gene Info

Gene Symbol	ITM2B
Full Name	Integral Membrane Protein 2B
Function	ITM2B/BRI2 is a transmembrane protein that undergoes constitutive processing by furin-like proprotein convertases, releasing a soluble BRI2 peptide.
Primary Expression	neurons throughout cortex, hippocampus, and cerebellum
Subcellular Localization	the brain. Neurobiology of Aging, 31(11), 1939-1947 (2010)](https://doi.org/10.1016/j.neurobiolaging.2009.11.006)
GeneCards	ITM2B
Human Protein Atlas	ITM2B
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ITM2B — Integral Membrane Protein 2B

gene · 519 words

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Pathway Diagram

graph TD
    ITM2B["ITM2B"]
    neurodegeneration["neurodegeneration"]
    ITM2B -->|"implicated_in"| neurodegeneration
    style ITM2B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ITM2B in their description or question text

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