Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL6R, IL6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| neuroinflammation | promoted: IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microglia Interface | disease | 0.63 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microgl | 0.831 | neuroinflammation | How do oligodendrocytes initiate neuroin |
Scientific analyses that reference this entity
neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.831
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson's di [PMID:39913287] | Ma Q, Tian JL, Lou Y, Guo R, Ma XR, Wu J | Cell Rep | 2025 | 1 |
| Axonal injury is a targetable driver of glioblastoma progression. [PMID:40836081] | Clements M, Tang W, Florjanic Baronik Z, | Nature | 2025 | 0 |
| CD38 in Neurodegeneration and Neuroinflammation. [PMID:32085567] | Guerreiro S, Privat AL, Bressac L, Toulo | Cells | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| CD38 in Neurodegeneration and Neuroinflammation. [PMID:32085567] | Guerreiro S, Privat AL, Bressac L, Toulo | Cells | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Microglia. [PMID:15554430] | ["van Rossum Denise", "Hanisch Uwe-Karst | Metabolic brain disease | 2004 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning IL6R, IL6 in their description or question text
No additional research found