protein

IL-34

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-34: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

4Outgoing

0Incoming

0Experiments

0Debates

Summary

Comprehensive review of Interleukin-34 (IL-34) cytokine in neurodegenerative diseases, with focus on microglial regulation, CSF1R signaling, Alzheimer's and Parkinson's disease mechanisms, and therapeutic targeting

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🔬 Protein Info

Gene Symbol	IL
Function	Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation.
GeneCards	IL
Human Protein Atlas	IL
Associated Diseases	CRC
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

IL-34 Protein

protein · 1897 words

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Pathway Diagram

graph TD
    IL_34(["IL-34"])
    NF_B_signaling_pathway["NF-kappaB signaling pathway"]
    cardiac_fibrosis["cardiac fibrosis"]
    IKK_phosphorylation["IKKbeta phosphorylation"]
    heart_failure["heart failure"]

    IL_34 -->|"activates"| NF_B_signaling_pathway
    IL_34 -->|"promotes"| cardiac_fibrosis
    IL_34 -->|"promotes"| IKK_phosphorylation
    IL_34 -->|"risk factor for"| heart_failure

    style IL_34 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style NF_B_signaling_pathway fill:#1a3a1a,stroke:#81c784,stroke-width:2px,color:#fff
    style cardiac_fibrosis fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff
    style IKK_phosphorylation fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff
    style heart_failure fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff

Outgoing (4)

Target	Relation	Type	Str
NF-κB signaling pathway	activates	pathway	0.95
cardiac fibrosis	promotes	phenotype	0.92
IKKβ phosphorylation	promotes	process	0.91
heart failure	risk_factor_for	disease	0.90

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL-34 in their description or question text

No additional research found