gene

HS3ST2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about HS3ST2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

hs3st2

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🧬 Gene Info

Gene Symbol	HS3ST2
Full Name	Heparan Sulfate-Glucosamine 3-Sulfotransferase 2
Chromosome	16p13.3
Protein Type	Enzyme
Function	is a gene encoding an enzyme critical for the biosynthesis of 3-O-sulfated heparan sulfate (3S-HS), a specialized form of heparan sulfate proteoglycans (HSPGs).
Primary Expression	neurons, particularly hippocampal neurons - Cellular localization: Located on the neuronal cell surface - Regulation: Upregulated by [TGFβ1](/
UniProt ID	Q9Y5P9
NCBI Gene ID	9956
GeneCards	HS3ST2
Human Protein Atlas	HS3ST2
Brain expression	Expressed in neurons, particularly hippocampal neurons
Cellular localization	Located on the neuronal cell surface
Regulation	Upregulated by TGFβ1 signaling
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HS3ST2 — AlphaFold Q9Y5P9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HS3ST2 Gene

gene · 641 words

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Pathway Diagram

graph TD
    HS3ST2["HS3ST2"]
    neurodegeneration["neurodegeneration"]
    HS3ST2 -->|"implicated_in"| neurodegeneration
    style HS3ST2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning HS3ST2 in their description or question text

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