Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HDL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Cholesterol | associated_with | chemical | 0.80 |
| Atherosclerotic Cardiovascular Disease | associated_with | disease | 0.70 |
| Atherosclerotic Cardiovascular Disease | protects_against | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ABCA1 | co_associated_with | gene | 0.30 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| HDL/apoE Particle Remodeling as a Therapeutic Switch for CAA | 0.766 | neurodegeneration | What molecular mechanisms explain how ap |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.766
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| ABCA1 rs2230806 polymorphism association with dementia risk in hyperli | exploratory | dementia, Alzheimer's disease | 0.900 | 0.00 | human patients | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Neuroprotective Effects of Berberine Chloride Against the Aluminium Chloride-Ind [PMID:40014257] | Uvarajan D, Gnanarajan R, Karuppusamy PA | Mol Biotechnol | 2026 | 0 |
| Multimodal Antiatherosclerotic Effects of Clinical-Grade Mesenchymal Stem Cell-D [PMID:41503702] | Kim J, Park D, Yoo J, Kim JE, Kim EH et | Stroke | 2026 | 0 |
| Interplay between cholesterol, Bis(monoacylglycerol)phosphate, and parasitophoro [PMID:41747887] | Hennot C, Leroux M, Lambert R, Boukherro | Biochimie | 2026 | 0 |
| Integrated Bioinformatics Analysis of a TF-miRNA-mRNA Regulatory Network in Reti [PMID:41755728] | Liang C, Xie H, Shi Q, Diao Y, Yu G et a | Curr Eye Res | 2026 | 0 |
| ApoE4 Drives Microglial Lipid Dysregulation in Alzheimer's Disease via Epigeneti [PMID:41808104] | Lin L, Pan Z, Wei Z, Jiang X, Lai Y et a | J Neuroinflammation | 2026 | 0 |
| Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzhei [PMID:41844011] | Wu L, Dong YT, Mu X, Luo X, Chen ZJ | J Prev Alzheimers Dis | 2026 | 0 |
| Atractylenolide I mitigates Alzheimer's disease pathology in ApoE (-/-) mice via [PMID:41877626] | Zhou X, Wang R, Yan J, Wu X, Yuan D et a | Acta Biochim Biophys Sin (Shan | 2026 | 0 |
| ABCA1-Mediated Structural Diversity of HDL Subspecies and Their Proposed Roles i [PMID:41884896] | Heinecke JW, Segrest JP, Phillips MC, Da | Arterioscler Thromb Vasc Biol | 2026 | 0 |
| Transcriptomic Analysis of High and Low Lipid Droplet Deposition Subpopulations [PMID:41897862] | Wang B, Li Y, Wang Y, Chen J, Wang J et | Animals (Basel) | 2026 | 0 |
| Chicoric acid enhanced brain cholesterol efflux and reduced Aβ pathology via LXR [PMID:41934727] | Li D, Zhang Y, Wang R, Jin L, Cui X et a | Neurotherapeutics | 2026 | 0 |
| Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzhei [PMID:41844011] | Wu L, Dong YT, Mu X, Luo X, Chen ZJ | The journal of prevention of A | 2026 | 0 |
| Transcriptomic Analysis of High and Low Lipid Droplet Deposition Subpopulations [PMID:41897862] | Wang B, Li Y, Wang Y, Chen J, Wang J, Li | Animals : an open access journ | 2026 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning HDL in their description or question text
No additional research found