protein

HAP40

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about HAP40: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for HAP40 Protein

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🔬 Protein Info

Gene Symbol	HAP40
Full Name	Huntingtin-Associated Protein 40
Function	HAP40 interacts with huntingtin and has several cellular functions
Primary Expression	Brain (high), peripheral tissues
Subcellular Localization	Potential role in neuronal toxicity
Molecular Weight	40 kDa
UniProt ID	Q9Y5R4
GeneCards	HAP40
Human Protein Atlas	HAP40
HAP40 Expression	Altered in HD brain
Pathogenic Interaction	Enhanced binding to mutant HTT
Toxicity	May contribute to neuronal dysfunction
Therapeutic Target	Disrupt HAP40-HTT interaction
Biomarker Potential	HAP40 levels as disease marker
HAP40-HTT interaction inhibitors	Block pathogenic binding
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: HAP40 — AlphaFold Q9Y5R4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HAP40 Protein

protein · 638 words

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Pathway Diagram

graph TD
    HAP40["HAP40"]
    neurodegeneration["neurodegeneration"]
    HAP40 -->|"implicated_in"| neurodegeneration
    style HAP40 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning HAP40 in their description or question text

No additional research found