Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Glial Senescence: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Autophagy Inhibition | associated_with | process | 0.85 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | in_progress | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.200 | 0.00 | Mouse (5xFAD/TREM2-/-) | in_progress | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214] | Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia | J Inflamm Res | 2022 | 1 |
| TREM2, microglia, and Alzheimer's disease. [PMID:33516818] | Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang | Mech Ageing Dev | 2021 | 1 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038] | Ulland TK, Song WM, Huang SC, Ulrich JD, | Cell | 2017 | 1 |
| The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663] | Krasemann S, Madore C, Cialic R, Baufeld | Immunity | 2017 | 1 |
| Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and T [PMID:41833042] | ["Lyu G", "Li D"] | CNS & neurological disorders d | 2026 | 0 |
| Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuro [PMID:41858793] | ["Wang R", "Feng Y", "Zhou Z", "Jiang J" | Frontiers in aging neuroscienc | 2026 | 0 |
| Human CSF proteogenomics links genetic variation to neurodegenerative disease pr [PMID:41757182] | ["Puerta R", "Garc\u00eda-Gonz\u00e1lez | medRxiv : the preprint server | 2026 | 0 |
| PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907] | Tsai AP, Martin AK, Mi A, Yeh AE, Ramire | Molecular neurodegeneration | 2026 | 0 |
| Opioid-induced transcriptional reprogramming of cerebrospinal fluid immune cells [PMID:41674808] | Acharya A, Ambikan AT, Neogi U, Lamberty | Res Sq | 2026 | 0 |
| Siah2 is a lipid-mediated metabolic sensor in adipose tissue macrophage. [PMID:41690475] | Dang TN, Ghosh B, Panta PR, Taylor JM, K | J Lipid Res | 2026 | 0 |
| PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907] | Tsai AP, Martin AK, Mi A, Yeh AE, Ramire | Mol Neurodegener | 2026 | 0 |
| TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604] | Yang HC, Deng YS, Zhang J, Zhang T, Song | J Alzheimers Dis | 2026 | 0 |
| Investigating the Potential of Gene Editing Technologies in Enhancing Stem Cell [PMID:41926312] | ["Mehrabadi S"] | Current aging science | 2026 | 0 |
| TREM2 in neurodegeneration and diseases. [PMID:41792456] | ["Abdulkhaliq A", "Alasiri G", "Kim B", | Molecular psychiatry | 2026 | 0 |
| Berbamine hydrochloride as a brain penetrant galectin 3 inhibitor in a model of [PMID:41772384] | ["Siew J", "Lee C", "Chen H", "Lin H", " | Brain : a journal of neurology | 2026 | 0 |
| The microglial TREM2 receptor programs hippocampal development in a mouse model [PMID:41887542] | Ahmed S, Bowers C, Munoz-Martin J, Jamwa | Brain, behavior, and immunity | 2026 | 0 |
| Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842] | Alhusaini M, Mussa BM, Ilce BY, Alhaj H, | Frontiers in aging neuroscienc | 2026 | 0 |
| Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial n [PMID:41881962] | Baek S, Jang J, Yeo S, Jung HJ, Choe Y | Signal transduction and target | 2026 | 0 |
| Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ4 [PMID:41770935] | ["Konstantoulea K", "Ramakers M", "Borri | Proceedings of the National Ac | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Glial Senescence in their description or question text
Score: 0.600 · neuroinflammation · 2026-04-22
## Mechanistic Overview APOE4 Induces Region-Specific Microglial Senescence Driving Frontal Cortex Neurodegeneration sta
Score: 0.582 · neurodegeneration · 2026-04-02
## Mechanistic Overview TREM2-Dependent Microglial Senescence Transition starts from the claim that modulating TREM2 wit
Score: 0.575 · neurodegeneration · 2026-04-25
High risk. The Expert identifies a fatal flaw: CD38 is predominantly expressed in peripheral immune cells (B cells, T ce
Score: 0.520 · neurodegeneration · 2026-04-22
## Mechanistic Overview Telomere Attrition and DNA Damage Response Activation Induces Microglial Senescence starts from
Score: 0.520 · neurodegeneration · 2026-04-22
## Mechanistic Overview Mitochondrial DNA Damage and cGAS-STING Activation Induces Microglial Senescence starts from the
Score: 0.459 · unknown disease · 2026-04-16
## Mechanistic Overview Selective Microglial Senescence Targeting via TREM2 Modulation starts from the claim that modula
Score: 0.000 · biomarkers · 2026-04-27
Site-specific glycosylation patterns on circulating TREM2 ectodomain fragments distinguish senescent from activated micr
Score: 0.000 · ALS · 2026-04-27
This hypothesis proposes that TBK1 loss-of-function mutations initiate a pathological cascade where microglia become loc