gene

GNG5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GNG5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

6Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for GNG5 — G Protein Subunit Gamma 5

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🧬 Gene Info

Gene Symbol	GNG5
Full Name	G Protein Subunit Gamma 5
Chromosome	1p22.2
Protein Family	G protein gamma subunit family
Function	encodes a widely expressed gamma subunit of heterotrimeric G proteins that plays essential roles in cellular signaling throughout the body.
Molecular Weight	7.7 kDa
Amino Acids	72 aa
Pathways	Wnt/β-catenin Pathway
UniProt ID	[P63218](https://www.uniprot.org/uniprot/P63218)
Ensembl ID	ENSG00000174021
OMIM	604774
GeneCards	GNG5
Human Protein Atlas	GNG5
C-terminal CAAX motif	Cys-Val-Ile-Met sequence for prenylation
Prenylation site	Geranylgeranylation at the cysteine residue
Associated Diseases	Breast Cancer, Colon Cancer, Essential Hypertension, Hypertriglyceridemia, Testicular Dysfunction
KG Connections	6 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GNG5 — G Protein Subunit Gamma 5

gene · 1594 words

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GNG5 Protein — G Protein Subunit Gamma 5

protein · 657 words

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Pathway Diagram

flowchart TD
    GNG5(["GNG5"])
    Breast_Cancer["Breast Cancer"]
    Glycolysis("Glycolysis")
    Colon_Cancer["Colon Cancer"]
    Wnt___catenin_Pathway["Wnt/beta-catenin Pathway"]
    Essential_Hypertension["Essential Hypertension"]
    Testicular_Dysfunction("Testicular Dysfunction")
    Hypertriglyceridemia["Hypertriglyceridemia"]
    neurodegeneration["neurodegeneration"]

    GNG5 -->|"associated with"| Breast_Cancer
    GNG5 -->|"upregulates"| Glycolysis
    GNG5 -->|"associated with"| Colon_Cancer
    GNG5 -->|"activates"| Wnt___catenin_Pathway
    GNG5 -->|"associated with"| Essential_Hypertension
    GNG5 -->|"associated with"| Testicular_Dysfunction
    GNG5 -->|"decreases risk"| Hypertriglyceridemia
    GNG5 -->|"implicated in"| neurodegeneration

    style GNG5 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (6)

Target	Relation	Type	Str
Colon Cancer	associated_with	disease	0.80
Breast Cancer	associated_with	disease	0.80
Wnt/β-catenin Pathway	activates	pathway	0.70
Essential Hypertension	associated_with	disease	0.70
Testicular Dysfunction	associated_with	phenotype	0.70
Hypertriglyceridemia	decreases_risk	disease	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GNG5 in their description or question text

No additional research found