Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | protects_against | process | 0.90 |
| MPP+ Toxicity | protects_against | process | 0.90 |
| Parkinson's Disease | treats | disease | 0.85 |
| TREM2 | modulates | protein | 0.70 |
| INHIBITORY_SYNAPSE | associated_with | gene | 0.70 |
| TREM2 | inhibits | protein | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| B3GALT4 | regulates | gene | 0.95 |
| GD3 Synthase Inhibition | upregulates | mechanism | 0.90 |
| ST3GAL2 | involved_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| GM1 Ganglioside Reduction via ST3GAL5 Activation to Block Aβ | 0.465 | lipidomics | Lipid metabolism dysregulation in Alzhei |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning GM1 in their description or question text
No additional research found