gene

GLRA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLRA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

1Outgoing

0Incoming

0Experiments

0Debates

Summary

Glycine receptor alpha-1 subunit

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🧬 Gene Info

Gene Symbol	GLRA1
Chromosome	5q33.1
Protein Type	Gene
Function	The GLRA1 gene encodes the Glycine Receptor Alpha-1, which mediates fast inhibitory neurotransmission in the spinal cord and brainstem.
Molecular Weight	52 kDa
Amino Acids	460 aa
Pathways	Recurrent Inhibition
GeneCards	GLRA1
Human Protein Atlas	GLRA1
Gene	GLRA1 (chromosome 5q33.1)
Protein Class	Ligand-gated chloride channel (Cys-loop receptor family)
Protein Size	460 amino acids
Primary Localization	Postsynaptic membranes of inhibitory neurons
Disease Associations	Hyperekplexia, epilepsy, autism spectrum disorders, neurodegenerative conditions
Therapeutic Relevance	Target for modulators of inhibitory neurotransmission
Associated Diseases	Hyperekplexia, epilepsy, autism spectrum disorders, neurodegenerative conditions
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GLRA1["GLRA1 Gene"]
    GlyR["Glycine Receptor Alpha-1 Subunit"]
    Glycine["Glycine Neurotransmitter"]
    Chloride["Chloride Ion Influx"]
    Inhibition["Neuronal Inhibition"]
    RecurrentInhibition["Recurrent Inhibition"]
    Hyperekplexia["Hyperekplexia"]
    Startle["Startle Response"]
    Spasticity["Spasticity"]
    MotorNeurons["Motor Neurons"]
    Brainstem["Brainstem Circuits"]
    SynapticTransmission["Synaptic Transmission"]
    GABA["GABA Receptors"]
    Excitotoxicity["Excitotoxicity"]
    Neurodegeneration["Neurodegeneration"]

    GLRA1 -->|"encodes"| GlyR
    Glycine -->|"binds to"| GlyR
    GlyR -->|"opens"| Chloride
    Chloride -->|"causes"| Inhibition
    Inhibition -->|"enables"| RecurrentInhibition
    GLRA1 -->|"mutations cause"| Hyperekplexia
    Hyperekplexia -->|"leads to"| Startle
    Hyperekplexia -->|"causes"| Spasticity
    GlyR -->|"expressed in"| MotorNeurons
    GlyR -->|"functions in"| Brainstem
    RecurrentInhibition -->|"regulates"| SynapticTransmission
    GABA -->|"cooperates with"| GlyR
    GlyR -->|"dysfunction leads to"| Excitotoxicity
    Excitotoxicity -->|"promotes"| Neurodegeneration

    style GLRA1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style GlyR fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    style RecurrentInhibition fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    style Hyperekplexia fill:#3a2a1a,stroke:#ffa726,stroke-width:2px
    style Excitotoxicity fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style Neurodegeneration fill:#3a1a1a,stroke:#ef5350,stroke-width:3px

Outgoing (1)

Target	Relation	Type	Str
Recurrent Inhibition	involved_in	process	0.85

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GLRA1 in their description or question text

No additional research found