gene

GJB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GJB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

GJB2 Gene

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🧬 Gene Info

Gene Symbol	GJB2
Chromosome	13q11-13
Protein Family	Connexin family
Protein Type	Channel
Function	During sound stimulation, potassium ions enter hair cells and must be recycled back to the endolymph through supporting cells expressing GJB2.
Subcellular Localization	Plasma membrane (gap junction)
Molecular Weight	26.2 kDa
UniProt ID	P29033
GeneCards	GJB2
Human Protein Atlas	GJB2
Four transmembrane domains	Form the channel pore
N- and C-terminal tails	Located in cytoplasm
Extracellular loops	Mediate docking with neighboring cells
Intracellular loop	Contains regulatory sites
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GJB2 — AlphaFold P29033 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GJB2 Gene

gene · 972 words

→

Connexin 26 (Gap Junction Beta-2) (GJB2)

protein · 784 words

→

Pathway Diagram

graph TD
    GJB2["GJB2"]
    neurodegeneration["neurodegeneration"]
    GJB2 -->|"implicated_in"| neurodegeneration
    style GJB2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GJB2 in their description or question text

No additional research found