Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GFRA2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GFRα2 (GDNF Family Receptor Alpha 2, encoded by the GFRA2 gene) is a GPI-anchored cell surface receptor that serves as the primary high-affinity receptor for neurturin (NRTN) and other GDNF family ligands.
No AI portrait yet
| Gene Symbol | GFRA2PROTEIN |
| Full Name | GFRα2 - GDNF Family Receptor Alpha 2 |
| Protein Type | Protein |
| Function | is a GPI-anchored cell surface receptor that serves as the primary high-affinity receptor for neurturin (NRTN) and other GDNF family ligands. |
| Subcellular Localization | Cell membrane (GPI-anchored), lipid rafts ; Protein Family : GDNF receptor f |
| Molecular Weight | 46 kDa |
| Amino Acids | 20 aa |
| UniProt ID | Search UniProt |
| GeneCards | GFRA2PROTEIN |
| Human Protein Atlas | GFRA2PROTEIN |
| GFRα2-a | Full-length form expressed in neurons |
| GFRα2-b | Truncated form with alternative splicing |
| GFRα2-c | Testis-specific isoform |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GFRA2PROTEIN["GFRA2PROTEIN"]
neurodegeneration["neurodegeneration"]
GFRA2PROTEIN -->|"implicated_in"| neurodegeneration
style GFRA2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GFRA2PROTEIN in their description or question text
No additional research found