Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GALECTIN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | GALECTIN3 |
| Full Name | Galectin-3 |
| Chromosome | 14q22.3 |
| Protein Type | Protein |
| Function | is a member of the galectin family of beta-galactoside-binding lectins that plays a multifaceted role in neurodegenerative disease pathogenesis. |
| Primary Expression | microglia, the resident immune cells of the brain, where it serves as a key marker of disease-associated microglia (DAM) or neurodegenerative microgli |
| Exons | 6 |
| UniProt ID | Search UniProt |
| GeneCards | GALECTIN3 |
| Human Protein Atlas | GALECTIN3 |
| C-terminal tail | Critical for lectin activity and multimerization |
| Microglia | Low baseline expression, dramatically upregulated in disease states |
| Astrocytes | Moderate expression in reactive astrocytes |
| Neurons | Minimal expression under normal conditions |
| Plaque association | Galectin-3 colocalizes with Aβ plaques in AD brain tissue, indicating direct binding to Aβ aggregates |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GALECTIN3["GALECTIN3"]
neurodegeneration["neurodegeneration"]
GALECTIN3 -->|"implicated_in"| neurodegeneration
style GALECTIN3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| h-immunity-03dc171e | relates_to | hypothesis | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
Neuroinflammation | 2026-04-03 | 4 hypotheses Top: 0.646
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning GALECTIN3 in their description or question text
No additional research found