gene

FGF22

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF22: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Gene profile: FGF22 - a synapse-specific FGF critical for presynaptic differentiation, synaptic vesicle organization, and nerve regeneration. Implicated in Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions through synaptic maintenance, plasticity, and axonal repair mechanisms.

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🧬 Gene Info

Gene Symbol	FGF22
Full Name	Fibroblast Growth Factor 22
Aliases	Gene profile: FGF22
Chromosome	19p13.3
Protein Type	Receptor
Function	is a secreted FGF family member with critical roles in synapse formation and presynaptic differentiation.
Primary Expression	striatal neurons
Subcellular Localization	synaptic sites where it provides retrograde signals to presynaptic neurons, promoting synaptic vesicle recruitment, acti
Pathways	signaling: \| Signal Source \| Target \| Effect \|, MAPK, PI3K
UniProt ID	Q9ULL0
NCBI Gene ID	27006
GeneCards	FGF22
Human Protein Atlas	FGF22
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FGF22 — AlphaFold Q9ULL0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

FGF22 — Fibroblast Growth Factor 22

gene · 991 words

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Pathway Diagram

graph TD
    FGF22["FGF22"]
    neurodegeneration["neurodegeneration"]
    FGF22 -->|"implicated in"| neurodegeneration
    Alzheimer_S_Disease{"Alzheimer'S Disease"}
    FGF22 -->|"implicated in"| Alzheimer_S_Disease
    Neurodegenerative_Conditions{"Neurodegenerative Conditions"}
    FGF22 -->|"implicated in"| Neurodegenerative_Conditions
    Parkinson_S_Disease{"Parkinson'S Disease"}
    FGF22 -->|"implicated in"| Parkinson_S_Disease
    Nerve_Regeneration(["Nerve Regeneration"])
    FGF22 -->|"promotes"| Nerve_Regeneration
    Presynaptic_Differentiation(["Presynaptic Differentiation"])
    FGF22 -->|"regulates"| Presynaptic_Differentiation
    Synaptic_Maintenance(["Synaptic Maintenance"])
    FGF22 -->|"regulates"| Synaptic_Maintenance
    Synaptic_Vesicle(["Synaptic Vesicle"])
    FGF22 -->|"regulates"| Synaptic_Vesicle
    FGF["FGF"]
    FGF22 ---|"interacts"| FGF
    style FGF22 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Alzheimer_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Parkinson_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Neurodegenerative_Conditions fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Presynaptic_Differentiation fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Synaptic_Maintenance fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Nerve_Regeneration fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Synaptic_Vesicle fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FGF22 in their description or question text

No additional research found