Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Epigenetic Reprogramming: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Therapeutic Utility | modulates | phenotype | 0.90 |
| Cellular Aging | modulates | process | 0.85 |
| Age-Related Phenotypes | modulates | phenotype | 0.80 |
| Age-Related Phenotype | treats | phenotype | 0.80 |
| Alzheimer's disease | regulates | disease | 0.70 |
| Neuroinflammation | activates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Rgfp966 | associated_with | drug | 0.85 |
| Hdac3 Inhibition | promotes | mechanism | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| NAD+ Decline and SIRT1 Deficiency Drive Epigenetic Reprogram | 0.700 | neurodegeneration | What molecular mechanisms drive microgli |
| FOXO3-Longevity Pathway Epigenetic Reprogramming | 0.672 | neurodegeneration | Epigenetic clocks and biological aging i |
| EV-Mediated Epigenetic Reprogramming | 0.665 | neurodegeneration | Extracellular vesicle biomarkers for ear |
| EV-Mediated Epigenetic Reprogramming | 0.661 | neurodegeneration | Extracellular vesicle biomarkers for ear |
| Epigenetic Reprogramming of Microglial Memory | 0.647 | Alzheimer's disease | Neuroinflammation and microglial priming |
| Epigenetic Reprogramming Required for Late-Stage Interventio | 0.542 | neurodegeneration | What is the optimal therapeutic window f |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Gandouling protection against brain injury in Wilson's disease via SIR | validation | Hepatolenticular degeneration | 0.900 | 0.00 | TX mice (Wilson's disease mode | proposed | N/A |
| Single-cell RNA sequencing of microglial states in AD hippocampus | exploratory | Alzheimer's disease | 0.850 | 0.00 | AD mouse hippocampus | proposed | N/A |
| Morphological characterization of microglial states in human brain | exploratory | Alzheimer's disease | 0.800 | 0.00 | human brain tissue | proposed | N/A |
| Proposed experiment from debate on Epigenetic clocks and biological ag | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $450,000 |
| Exercise-BDNF-Mitophagy Biomarker Study in PD | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develo | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| Experiment Design: Metal Ion-Synuclein-Mitochondria Axis in Parkinson' | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression a [PMID:40752494] | Liu Z, Zhang S, James BT, Galani K, Mang | Cell | 2025 | 1 |
| Utilization of fluid-based biomarkers as endpoints in disease-modifying clinical [PMID:38678292] | Oosthoek M, Vermunt L, de Wilde A, Bonge | Alzheimer's research & therapy | 2024 | 1 |
| Increased mitophagy protects cochlear hair cells from aminoglycoside-induced dam [PMID:35471096] | Zhang Y, Fang Q, Wang H, Qi J, Sun S, Li | Autophagy | 2023 | 1 |
| Detailed stratified GWAS analysis for severe COVID-19 in four European populatio [PMID:35848942] | Degenhardt F, Ellinghaus D, Juzenas S, L | Human molecular genetics | 2022 | 1 |
| Fifteen-minute consultation: Therapeutic hypothermia for infants with hypoxic is [PMID:31292147] | Cawley P, Chakkarapani E | Arch Dis Child Educ Pract Ed | 2020 | 1 |
| Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Hom [PMID:29548672] | Datta M, Staszewski O, Raschi E, Frosch | Immunity | 2018 | 1 |
| Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve reg [PMID:30135423] | Sahoo PK, Lee SJ, Jaiswal PB, Alber S, K | Nat Commun | 2018 | 1 |
| EB1 and EB3 regulate microtubule minus end organization and Golgi morphology. [PMID:28814570] | Yang C, Wu J, de Heus C, Grigoriev I, Li | J Cell Biol | 2017 | 1 |
| Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines [PMID:26746105] | Herbert J, Lucassen PJ | Frontiers in neuroendocrinolog | 2016 | 1 |
| c-Rel Regulates Inscuteable Gene Expression during Mouse Embryonic Stem Cell Dif [PMID:26694615] | Ishibashi R, Kozuki S, Kamakura S, Sumim | J Biol Chem | 2016 | 1 |
| DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperate [PMID:24652652] | Polato F, Rusconi P, Zangrossi S, Morell | J Natl Cancer Inst | 2014 | 1 |
| IRF4 addiction in multiple myeloma. [PMID:18568025] | Shaffer AL, Emre NC, Lamy L, Ngo VN, Wri | Nature | 2008 | 1 |
| Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and T [PMID:41833042] | ["Lyu G", "Li D"] | CNS & neurological disorders d | 2026 | 0 |
| Guishen-erxian decoction can improve ovarian function in rats with premature ova [PMID:40931880] | Zhong H, He Y, Wang W, Liu Y, Chen D et | Histol Histopathol | 2026 | 0 |
| Metabolic surgery mitigates early kidney injury in obese youth with diabetes by [PMID:41665972] | Naik AS, Alakwaa FM, Nair V, McCown PJ, | J Clin Invest | 2026 | 0 |
| FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by [PMID:41860561] | Wu ZL, Ran R, Xie QQ, Zhang C, Chen YJ e | Aging Cell | 2026 | 0 |
| Kaempferol Mitigates Liver Injury Induced by Copper Toxicity Through the Activat [PMID:41891498] | Xu J, Wan W, Mu H, Gong S, Liu Y et al. | J Biochem Mol Toxicol | 2026 | 0 |
| IL-27-Ucp2-FoxO3 axis mediating the polarization of alternatively activated macr [PMID:41918304] | Ma Y, Gan S, Zheng Y, Kang X, Zhu S | Korean J Pain | 2026 | 0 |
| Dnmt3a-mediated hypermethylation of FoxO3 promotes redox imbalance during osteoc [PMID:40106360] | Zhang W, Li W, Du J, Yang C, Yu L, Yang | Proceedings of the National Ac | 2025 | 0 |
| Mitochondrial dysfunction and aging: multidimensional mechanisms and therapeutic [PMID:40634825] | Wei P, Zhang X, Yan C, Sun S, Chen Z, Li | Biogerontology | 2025 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Epigenetic Reprogramming in their description or question text