Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Ephrin-EphB receptor signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| EPHB4 | participates_in | gene | 0.38 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Ephrin-B2/EphB4 Axis Manipulation | 0.645 | neurodegeneration | 4R-tau strain-specific spreading pattern |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.732
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Spatial transcriptomic analysis of multistage ESCC development | exploratory | esophageal squamous-cell carci | 0.850 | 0.00 | human patients and mice | proposed | N/A |
| Functional analysis of EFNB1-EPHB4 interaction in EMT | exploratory | esophageal squamous-cell carci | 0.800 | 0.00 | cell culture systems and tissu | proposed | N/A |
| Analysis of TP53-TP63/ΔNP63-EFNB1-EPHB4 axis in cancer progression | exploratory | esophageal squamous-cell carci | 0.750 | 0.00 | human ESCC tissue samples and | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma [PMID:38097539] | Chen L, Zhu S, Liu T, Zhao X, Xiang T, H | Signal Transduct Target Ther | 2023 | 1 |
| Icariin Alleviates Glucocorticoid-Induced Osteoporosis through EphB4/Ephrin-B2 A [PMID:32508946] | Huang M, Wang Y, Peng R | Evid Based Complement Alternat | 2020 | 1 |
| EphrinB2-EphB4-RASA1 Signaling in Human Cerebrovascular Development and Disease. [PMID:30819650] | Zeng X, Hunt A, Jin SC, Duran D, Gaillar | Trends Mol Med | 2019 | 1 |
| Working with children and young people in research: Supportive practices and pat [PMID:37186542] | ["Thomas C", "Cockcroft E", "Jenkins G", | Journal of child health care : | 2025 | 0 |
| Manipulating the EphB4-ephrinB2 axis to reduce metastasis in HNSCC. [PMID:39489818] | Abdelazeem KNM, Nguyen D, Corbo S, Darra | Oncogene | 2025 | 0 |
| Replacing Dietary Fish Meal with Defatted Black Soldier Fly ( [PMID:35492617] | ["Li X", "Qin C", "Fang Z", "Sun X", "Sh | Frontiers in physiology | 2022 | 0 |
| Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine [PMID:34756178] | ["Declercq J", "Van Damme K", "De Leeuw | The Lancet. Respiratory medici | 2021 | 0 |
| Predictive factors of volumetric reduction in lumbar disc herniation treated by [PMID:32945283] | ["Negro A", "Paolucci A", "Russo C", "Di | Acta bio-medica : Atenei Parme | 2020 | 0 |
| Variation in Intensive Care Unit Intubation Practices in Pulmonary Critical Care [PMID:33728421] | ["Brady A", "Brown W", "Denson J", "Wint | ATS scholar | 2020 | 0 |
| The predominance of nucleotidyl activation in bacterial phosphonate biosynthesis [PMID:31420548] | ["Rice K", "Batul K", "Whiteside J", "Ke | Nature communications | 2019 | 0 |
| A review of the impact of financing mechanisms on maternal health care in Austra [PMID:31752792] | ["Fox H", "Topp S", "Callander E", "Lind | BMC public health | 2019 | 0 |
| Molecular identity of arteries, veins, and lymphatics. [PMID:30154011] | Wolf K, Hu H, Isaji T, Dardik A | Journal of vascular surgery | 2019 | 0 |
| Vitamin D3 Induces Gene Expression of Ox-LDL Scavenger Receptors in Streptozotoc [PMID:29766000] | Alizadeh S, Mirshafiey A, Djalali M, Alv | Reports of biochemistry & mole | 2018 | 0 |
| Focal molography is a new method for the in situ analysis of molecular interacti [PMID:28945239] | ["Gatterdam V", "Frutiger A", "Stengele | Nature nanotechnology | 2017 | 0 |
| Translating RNA sequencing into clinical diagnostics: opportunities and challeng [PMID:26996076] | ["Byron S", "Van Keuren-Jensen K", "Enge | Nature reviews. Genetics | 2016 | 0 |
| Superimposed electrical stimulation improves mobility of pre-stiff thumbs after [PMID:24894392] | ["Moineau B", "Boisgontier M"] | Annals of physical and rehabil | 2014 | 0 |
| Metastatic soft tissue sarcoma diagnosed by small bowel video capsule endoscopy. [PMID:20368563] | Jennifer M Weiss; Steven Attia; Howard H | Journal of clinical oncology : | 2010 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.69 · 2026-04-12
closed · Rounds: 7 · Score: 0.91 · 2026-04-10
Hypotheses and analyses mentioning Ephrin-EphB receptor signaling in their description or question text
No additional research found