gene

ESCO1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about ESCO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for ESCO1 - Establishment of Sister Chromatid Cohesion N-Acetyltransferase 1

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🧬 Gene Info

Gene Symbol	ESCO1
Full Name	Establishment of Sister Chromatid Cohesion N-Acetyltransferase 1
Aliases	Page for ESCO1
Protein Type	Transferase
Function	is a lysine acetyltransferase that modifies the SMC3 subunit of the cohesin complex, a critical step in establishing sister chromatid cohesion during DNA replication.
UniProt ID	Q5F2C3
Ensembl ID	ENSG00000131931
GeneCards	ESCO1
Human Protein Atlas	ESCO1
Stabilizes cohesive interactions	Locks cohesin onto chromatin to maintain sister chromatid cohesion
Protects from WAPL-mediated release	Prevents premature cohesin unloading
Establishes functional cohesin	Generates the cohesin form competent for S phase functions[@unal2008]
ESCO1	Constitutively expressed, acetylates cohesin throughout the cell cycle, involved in DNA damage response
ESCO2	S-phase specific, critical for replication-coupled cohesion establishment[@alomer2017]
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ESCO1 — AlphaFold Q5F2C3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ESCO1 - Establishment of Sister Chromatid Cohesion N-Acetyltransferase 1

gene · 643 words

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Pathway Diagram

graph TD
    ESCO1["ESCO1"]
    neurodegeneration["neurodegeneration"]
    ESCO1 -->|"implicated_in"| neurodegeneration
    style ESCO1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning ESCO1 in their description or question text

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