Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ERCC4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ERCC4 |
| Chromosome | 16p13.12 |
| Protein Type | Gene |
| Function | ERCC4 (XPF) forms a heterodimer with ERCC1 (XPF-ERCC1 complex) that functions as: |
| Primary Expression | most tissues: - Highest in: - Testis - Ovary - Bone marrow - Skin - Moderate expression in: - Brain (neurons and astrocytes) - Liver - K |
| Ensembl ID | ENSG00000175595 |
| GeneCards | ERCC4 |
| Human Protein Atlas | ERCC4 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ERCC4["ERCC4"]
neurodegeneration["neurodegeneration"]
ERCC4 -->|"implicated_in"| neurodegeneration
style ERCC4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ERCC4 in their description or question text
No additional research found