gene

EPHB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPHB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

EPHB1 (Eph Receptor B1) is a member of the Eph receptor tyrosine kinase family involved in neural development, synaptic plasticity, and neurodegenerative disease pathogenesis.

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🧬 Gene Info

Gene Symbol	EPHB1
Full Name	Eph Receptor B1
Chromosome	3p21.2
Protein Type	Receptor
Function	is a member of the Eph receptor tyrosine kinase family that plays crucial roles in neural development, synaptic plasticity, and cellular communication within the central nervous system.
Primary Expression	the developing nervous system, where it plays critical roles in neuronal migration, axon guidance, and target selection
Subcellular Localization	both pre-synaptic and post-synaptic compartments, where it participates in bidirectional signaling with ephrin-B ligands
Molecular Weight	110 kDa
UniProt ID	P08620
Ensembl ID	ENSG00000155090
GeneCards	EPHB1
Human Protein Atlas	EPHB1
Associated Diseases	Alzheimer's disease, Parkinson's disease, brain development disorders
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: EPHB1 — AlphaFold P08620 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

EPHB1 Gene

gene · 2186 words

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Pathway Diagram

graph TD
    EPHB1["EPHB1"]
    neurodegeneration["neurodegeneration"]
    EPHB1 -->|"implicated_in"| neurodegeneration
    style EPHB1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning EPHB1 in their description or question text

No additional research found