gene

EPHA7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPHA7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

0Outgoing

1Incoming

0Experiments

0Debates

Summary

Ephrin Type-A Receptor 7, a receptor tyrosine kinase involved in neuronal development, synaptic plasticity, and tumor suppression

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🧬 Gene Info

Gene Symbol	EPHA7
Full Name	Ephrin Type-A Receptor 7
Chromosome	6q16.1.
Protein Type	Receptor
Function	Neuronal Migration: During cortical development, EPHA7 guides migrating neurons to their correct positions in the developing cortex[@wang2018].
Primary Expression	Neurons, Astrocytes, Oligodendrocyte precursors
Molecular Weight	110 kDa
Amino Acids	983 aa
Exons	17
UniProt ID	Q9Y232
NCBI Gene ID	2845
Ensembl ID	ENSG00000126890
OMIM	602088
GeneCards	EPHA7
Human Protein Atlas	EPHA7
Associated Diseases	Alzheimer's Disease, Parkinson's Disease, Cancer (tumor suppressor)
KG Connections	1 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EPHA7 — AlphaFold Q9Y232 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

EPHA7 Gene

gene · 3390 words

→

Pathway Diagram

flowchart TD
    N0["EPHA7"]
    N1["TCF/LEF"]
    N1 -->|"binds"| N0
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
TCF/LEF	binds	transcription_factor	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EPHA7 in their description or question text

No additional research found