gene

ELP4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ELP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

0Hypotheses

0Analyses

2Outgoing

1Incoming

0Experiments

0Debates

Summary

Elongator acetyltransferase complex subunit 4 - tRNA modification and neurodevelopment

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🧬 Gene Info

Gene Symbol	ELP4
Full Name	Elongator Subunit 4
Aliases	Elongator acetyltransferase complex subunit 4
Chromosome	11p13
Protein Family	Elongator family
Function	encodes a non-catalytic component of the Elongator complex that plays critical roles in tRNA modification, RNA processing, and neuronal development[@elp4_function].
Gene Type	Protein-coding
UniProt ID	Q9BYH4
NCBI Gene ID	23525
Ensembl ID	ENSG00000109099
OMIM	607234
GeneCards	ELP4
Human Protein Atlas	ELP4
tRNA recruitment	Binds to specific tRNA species for modification
Substrate specificity	Determines which tRNAs are modified
Associated Diseases	Benign Epilepsy with Centrotemporal Spikes, Rolandic Epilepsy
Interactions	Elongator
KG Connections	3 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ELP4 — AlphaFold Q9BYH4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ELP4 Gene

gene · 1120 words

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Pathway Diagram

graph TD
    ELP4["ELP4"]
    Elongator(["Elongator"])
    Benign_Epilepsy_with_Centrotemporal_Spik["Benign Epilepsy with Centrotemporal Spikes"]
    Rolandic_Epilepsy["Rolandic Epilepsy"]
    neurodegeneration["neurodegeneration"]

    Elongator -->|"interacts with"| ELP4
    ELP4 -->|"associated with"| Benign_Epilepsy_with_Centrotemporal_Spik
    ELP4 -->|"associated with"| Rolandic_Epilepsy
    ELP4 -->|"implicated in"| neurodegeneration

    style ELP4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Elongator fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff
    style Benign_Epilepsy_with_Centrotemporal_Spik fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    style Rolandic_Epilepsy fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff

Outgoing (2)

Target	Relation	Type	Str
Benign Epilepsy with Centrotemporal Spikes	associated_with	disease	0.60
Rolandic Epilepsy	associated_with	disease	0.60

Incoming (1)

Source	Relation	Type	Str
Elongator	interacts_with	protein	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ELP4 in their description or question text

No additional research found