Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EIF2B1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | EIF2B1 |
| Chromosome | 12q24.31 |
| Protein Type | Gene |
| Function | EIF2B1 encodes the alpha subunit of eukaryotic translation initiation factor 2B (eIF2B), which is the guanine nucleotide exchange factor (GEF) for eIF2. |
| Primary Expression | all tissues, with high expression in the brain, particularly in oligodendrocytes, astrocytes, and neurons |
| Molecular Weight | 33 kDa |
| Ensembl ID | ENSG00000111361 |
| GeneCards | EIF2B1 |
| Human Protein Atlas | EIF2B1 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
EIF2B1["EIF2B1"]
neurodegeneration["neurodegeneration"]
EIF2B1 -->|"implicated_in"| neurodegeneration
style EIF2B1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning EIF2B1 in their description or question text
No additional research found