Degeneration

The debate highlighted compelling correlative evidence for ferroptosis markers i

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Elevated CSF/Serum Albumin Quotient Predicts Neurodegeneration Progression Indep

Score: 0.850 · unknown disease · 2026-04-26

Serum albumin is synthesized exclusively by the liver and absent from CNS under normal BBB. When barrier permeability in

Neutral Sphingomyelinase-2 Inhibition for Synaptic Protection in Neurodegenerati

Score: 0.844 · neurodegeneration · 2026-04-07

## Mechanistic Overview Neutral Sphingomyelinase-2 Inhibition for Synaptic Protection in Neurodegeneration starts from t

Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-Synuclein Aggregates

Score: 0.822 · neurodegeneration · 2026-04-05

## Mechanistic Overview Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-Synuclein Aggregates Drives Non-Cell-

Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in Neurodegeneration

Score: 0.805 · neurodegeneration · 2026-04-05

## Mechanistic Overview Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in Neurodegeneration starts from the cla

Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Release Mechanism for

Score: 0.804 · neurodegeneration · 2026-04-05

## Mechanistic Overview Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Release Mechanism for AIM2 Inflammasom

Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neurodegeneration

Score: 0.803 · neurodegeneration · 2026-04-05

## Mechanistic Overview Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neurodegeneration starts from the claim

ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degen

Score: 0.801 · Alzheimer's Disease · 2026-04-05

## Mechanistic Overview ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degeneration in Alzhe

ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlie

Score: 0.779 · Alzheimer's Disease · 2026-04-05

## Mechanistic Overview ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlies White Matter D

Circulating Soluble PDGFRβ Reflects Pericyte Loss and Precedes Cognitive Decline

Score: 0.745 · unknown disease · 2026-04-26

Soluble PDGFRβ (sPDGFRβ) is released into the bloodstream upon pericyte damage, serving as a peripheral indicator of blo

Endosomal trafficking defects are the common upstream lesion linking APP process

Score: 0.730 · neurodegeneration · 2026-04-25

AD-risk trafficking defects in SORL1/BIN1/PICALM/retromer may generate parallel early outputs: amyloidogenic APP sorting

CSF/Plasma AQP4 Polarization Index as a Novel Biomarker of Astrocyte Glymphatic

Score: 0.705 · unknown disease · 2026-04-26

Aquaporin-4 (AQP4) water channels are normally concentrated at astrocyte end-feet ensheathing cerebral microvessels. Ear

Soluble PDGFRβ as a Peripheral Indicator of Pericyte-Mediated Blood-Brain Barrie

Score: 0.705 · unknown disease · 2026-04-26

Pericyte loss in Alzheimer's disease leads to proteolytic shedding of PDGFRβ into circulation, providing a blood-accessi

SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-Dependent Axon Degene

Score: 0.698 · neurodegeneration · 2026-04-14

## Mechanistic Overview SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-Dependent Axon Degeneration starts fr

Astrocyte-Neuron Metabolic Coupling Failure Precedes Neurodegeneration in FTD-GR

Score: 0.690 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The pathogenesis of frontotemporal dementia with GRN mutations (FTD-GRN) involves

Microglia and complement sustain post-Aβ neurodegeneration after tau missorting

Score: 0.690 · neurodegeneration · 2026-04-25

Aβ initiates tau missorting, but persistent degeneration is then maintained by activated microglia through C1q/C3-CR3-me