gene

DYNLT1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about DYNLT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

DYNLT1 gene encodes Tctex-1 dynein light chain, essential for retrograde axonal transport. Critical for neuronal survival and implicated in Alzheimer's, Parkinson's, and Huntington's diseases.

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🧬 Gene Info

Gene Symbol	DYNLT1
Full Name	Dynein Light Chain Tctex-Type 1
Chromosome	6q21
Function	is a large multi-subunit motor protein complex essential for retrograde transport in all eukaryotic cells.
Molecular Weight	500 kDa
Amino Acids	110 aa
UniProt ID	P63172
NCBI Gene ID	6993
Ensembl ID	ENSG00000126653
OMIM	162376
GeneCards	DYNLT1
Human Protein Atlas	DYNLT1
DYNLT1 (Tctex-1)	The Tctex-type light chain
DYNLT2	Another Tctex family member
DYNLRB1/DYNLRB2 (Roadblock)	The roadblock-type light chains
Associated Diseases	Alzheimer's disease, Parkinson's disease, Huntington's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DYNLT1 — AlphaFold P63172 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DYNLT1 — Dynein Light Chain Tctex-Type 1

gene · 2182 words

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Pathway Diagram

graph TD
    DYNLT1["DYNLT1"]
    neurodegeneration["neurodegeneration"]
    DYNLT1 -->|"implicated_in"| neurodegeneration
    style DYNLT1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning DYNLT1 in their description or question text

No additional research found