protein

DYNC1I2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DYNC1I2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

DYNC1I2 encodes the intermediate chain of cytoplasmic dynein 1, the major minus-end-directed microtubule motor. Critical for retrograde axonal transport, organelle trafficking, and neuronal homeostasis. Dysfunction causes hereditary spastic paraplegia and other transport-related neurodegenerative disorders.

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🔬 Protein Info

Gene Symbol	DYNC1I2
Function	The DYNC1I2 gene encodes Dynein Intermediate Chain Protein, a protein involved in various cellular processes relevant to neuronal function and survival.
Primary Expression	various brain regions, with notable expression in: - Cerebral cortex - Hippocampus - Basal gang
Molecular Weight	71 kDa
Amino Acids	650 aa
Ensembl ID	ENSG00000077380
GeneCards	DYNC1I2
Human Protein Atlas	DYNC1I2
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DYNC1I2 Gene

gene · 522 words

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DYNC1I2 Protein

protein · 1552 words

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Pathway Diagram

graph TD
    DYNC1I2["DYNC1I2"]
    neurodegeneration["neurodegeneration"]
    DYNC1I2 -->|"implicated in"| neurodegeneration
    Hereditary_Spastic_Paraplegia{"Hereditary Spastic Paraplegia"}
    DYNC1I2 -->|"implicated in"| Hereditary_Spastic_Paraplegia
    Neurodegenerative_Disorders{"Neurodegenerative Disorders"}
    DYNC1I2 -->|"implicated in"| Neurodegenerative_Disorders
    Axonal_Transport(["Axonal Transport"])
    DYNC1I2 -->|"regulates"| Axonal_Transport
    Microtubule(["Microtubule"])
    DYNC1I2 -->|"regulates"| Microtubule
    Neuronal_Homeostasis(["Neuronal Homeostasis"])
    DYNC1I2 -->|"regulates"| Neuronal_Homeostasis
    Retrograde_Axonal_Transport(["Retrograde Axonal Transport"])
    DYNC1I2 -->|"regulates"| Retrograde_Axonal_Transport
    style DYNC1I2 fill:#1a4a3a,stroke:#81c784,stroke-width:3px,color:#fff
    style Neurodegenerative_Disorders fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Hereditary_Spastic_Paraplegia fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Retrograde_Axonal_Transport fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Neuronal_Homeostasis fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Axonal_Transport fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Microtubule fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

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Related Research

Hypotheses and analyses mentioning DYNC1I2 in their description or question text

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