gene

DUSP12

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about DUSP12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for DUSP12 Gene

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🧬 Gene Info

Gene Symbol	Dual Specificity Phosphatase 12
Chromosome	1q21.2
Protein Type	Phosphatase
Function	DUSP12 encodes a dual-specificity phosphatase protein that belongs to the MAPK phosphatase (MKP) family.
Subcellular Localization	Phosphatase Domain: Conserved catalytic domain containing the HCX5R motif
Pathways	MAPK, MAPK signaling
UniProt ID	Q9Y5P4
NCBI Gene ID	57162
Ensembl ID	ENSG00000132359
OMIM	613955
JNK (c-Jun N-terminal Kinase)	Critical for stress response and apoptosis
p38 MAPK	Regulates inflammatory responses and cell death pathways
N-terminal Domain	Regulatory sequences potentially involved in subcellular localization
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DUSP12 — AlphaFold Q9Y5P4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DUSP12 Gene

gene · 770 words

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Pathway Diagram

graph TD
    DUSP12["DUSP12"]
    neurodegeneration["neurodegeneration"]
    DUSP12 -->|"implicated_in"| neurodegeneration
    style DUSP12 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning DUSP12 in their description or question text

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