Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DLG3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Gene Symbol | DLG3 |
| Chromosome | Xq13.1 |
| Protein Type | Scaffold Protein |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Pathways | PI3K |
| UniProt ID | Q9UQB5 |
| NCBI Gene ID | 1741 |
| Ensembl ID | ENSG00000165682 |
| GeneCards | DLG3 |
| Human Protein Atlas | DLG3 |
| PDZ domains | Bind to NMDA receptor subunits (GluN2A, GluN2B), Kv1.x potassium channels |
| SH3 domain | Interacts with proline-rich proteins |
| GK domain | Associates with GKAP proteins, linking to larger scaffold complexes |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DLG3["DLG3"]
neurodegeneration["neurodegeneration"]
DLG3 -->|"implicated_in"| neurodegeneration
style DLG3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| LAMP2B | associated_with | gene | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DLG3 in their description or question text
No additional research found