gene

DLG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DLG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

6Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for DLG1 — Discs Large Homolog 1

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🧬 Gene Info

Gene Symbol	DLG1
Full Name	Discs Large Homolog 1
Aliases	MAGUK Scaffold
Chromosome	3q29
Protein Type	Scaffold Protein
Function	DLG1/MAGUK scaffold protein functions in: - Synaptic organization: Forms core of postsynaptic density - NMDA receptor anchoring: Recruits NMDA and AMPA receptors to synapses - Synaptic plasticity: Ess
Primary Expression	excitatory glutamatergic neurons, particularly in pyramidal neurons of layers 2/3 and 5 of the cerebral cortex
Molecular Weight	102 kDa
Amino Acids	922 aa
UniProt ID	Q12959
NCBI Gene ID	1739
Ensembl ID	ENSG00000075711
OMIM	601014
GeneCards	DLG1
Human Protein Atlas	DLG1
Associated Diseases	neurodegeneration
Interactions	GJA1
KG Connections	7 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DLG1 — AlphaFold Q12959 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DLG1 — Discs Large Homolog 1

gene · 714 words

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DLG1 — Discs Large Homolog 1 Protein (MAGUK Scaffold)

protein · 688 words

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Pathway Diagram

flowchart TD
    N0["DLG1"]
    N1["GJA1"]
    N1 -->|"interacts with"| N0
    N0 -->|"regulates"| N1
    N2["Wound Healing"]
    N0 -->|"contributes to"| N2
    N3["Cell Proliferation"]
    N0 -->|"regulates"| N3
    N4["Cell Shape"]
    N0 -->|"regulates"| N4
    N5["Cell Polarity"]
    N0 -->|"regulates"| N5
    N6["Cell Migration"]
    N0 -->|"involved in"| N6
    N7["neurodegeneration"]
    N0 -->|"implicated in"| N7

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 gene
    class N1 gene
    class N2 process
    class N3 process
    class N4 phenotype
    class N5 phenotype
    class N6 process

Outgoing (6)

Target	Relation	Type	Str
GJA1	regulates	gene	0.90
Wound Healing	contributes_to	process	0.90
Cell Proliferation	regulates	process	0.85
Cell Shape	regulates	phenotype	0.85
Cell Polarity	regulates	phenotype	0.85
Cell Migration	involved_in	process	0.80

Incoming (1)

Source	Relation	Type	Str
GJA1	interacts_with	gene	0.95

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DLG1 in their description or question text

No additional research found