gene

DDR2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DDR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

Gene: DDR2 encodes a receptor tyrosine kinase involved in neuronal survival, collagen signaling, and Parkinson's disease risk.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	DDR2
Full Name	Discoidin Domain Receptor 2
Aliases	TKT, NTRKR3
Chromosome	1q23.3
Protein Type	Receptor
Function	Collagen binding induces DDR2 autophosphorylation and downstream signaling through
Primary Expression	Brain, cartilage, bone, lung, kidney
Amino Acids	896 aa
Pathways	MAPK pathway, PI3K
UniProt ID	Q16832
NCBI Gene ID	4921
Ensembl ID	ENSG00000137337
GeneCards	DDR2
Human Protein Atlas	DDR2
Extracellular domain	Contains a DS (discoidin) domain that binds collagen
Associated Diseases	Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DDR2 — AlphaFold Q16832 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DDR2 — Discoidin Domain Receptor 2

gene · 802 words

→

Pathway Diagram

graph TD
    DDR2["DDR2"]
    neurodegeneration["neurodegeneration"]
    DDR2 -->|"implicated_in"| neurodegeneration
    style DDR2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DDR2 in their description or question text

No additional research found