gene

DDB2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about DDB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

DDB2 (DNA Damage Binding Protein 2 / XPE) - DNA damage recognition protein in nucleotide excision repair. Associated with Xeroderma Pigmentosum, neurodegeneration, cancer, and Alzheimer's disease.

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🧬 Gene Info

Gene Symbol	DDB2
Full Name	DNA Damage Binding Protein 2 (XPE)
Aliases	DNA Damage Binding Protein 2 / XPE
Chromosome	11q12.1
Function	is a crucial DNA damage recognition protein that functions as the substrate recognition subunit of the CUL4-DDB1 ubiquitin ligase complex.
Amino Acids	427 aa
Exons	10
UniProt ID	Q13435
NCBI Gene ID	1643
Ensembl ID	ENSG00000113889
OMIM	601421
GeneCards	DDB2
Human Protein Atlas	DDB2
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DDB2 — AlphaFold Q13435 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DDB2 Gene

gene · 3517 words

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Pathway Diagram

graph TD
    DDB2["DDB2"]
    neurodegeneration["neurodegeneration"]
    DDB2 -->|"implicated_in"| neurodegeneration
    style DDB2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning DDB2 in their description or question text

No additional research found