Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Circadian clock / CLOCK-BMAL1 transcription: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Circadian Clock-Autophagy Synchronization | 0.763 | neurodegeneration | Sleep disruption as cause and consequenc |
| Circadian-Synchronized Proteostasis Enhancement | 0.744 | neurodegeneration | Digital biomarkers and AI-driven early d |
| Temporal Decoupling via Circadian Clock Reset | 0.543 | neurodegeneration | Microglia-astrocyte crosstalk amplificat |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.756
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.729
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Circadian gene expression effects of SD vs ketamine | exploratory | depression | 0.950 | 0.00 | C57BL/6J mice | proposed | N/A |
| CLOCK/BMAL1 regulation of ICC autophagy in GERD model | exploratory | gastroesophageal reflux diseas | 0.900 | 0.00 | primary esophageal interstitia | proposed | N/A |
| Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Proposed experiment from debate on Epigenetic clocks and biological ag | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| Circadian-Vascular-Metabolic Syndrome (CVMS) Intervention Trial | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,900,000 |
| Experiment Index | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Macroautophagy Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| N-of-1 Clinical Trial Design for CBS/PSP | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Normal Aging to Alzheimer's Disease Transition Trigger — Identifying t | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Autophagy Enhancement Drug Screening for Neurodegeneration | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Brainstem Circuit Modulation for PSP | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Chaperone-Mediated Autophagy Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Experiment Scoring Methodology | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Sleep and Circadian Dysfunction as Driver of Neurodegeneration | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| CRISPR Gene Correction Approaches for CBS/PSP | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Neural Oscillation Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Circadian Rhythms in Gastroenterology: The Biological Clock's Impact on Gut Heal [PMID:40588189] | Bishehsari F, Post Z, Swanson GR, Keshav | Gastroenterology | 2025 | 1 |
| From geroscience to precision geromedicine: Understanding and managing aging. [PMID:40250404] | Kroemer G, Maier AB, Cuervo AM, Gladyshe | Cell | 2025 | 1 |
| Circadian disruption, clock genes, and metabolic health. [PMID:39007272] | Schrader LA, Ronnekleiv-Kelly SM, Hogene | J Clin Invest | 2024 | 1 |
| BMAL1 involved in autophagy and injury of thoracic aortic endothelial cells of r [PMID:37086572] | Chunli Yang, Ziwei Deng, Qihang Zeng, Xi | Biochemical and biophysical re | 2023 | 1 |
| Biomarkers of aging for the identification and evaluation of longevity intervent [PMID:37657418] | Moqri M, Herzog C, Poganik JR, Biomarker | Cell | 2023 | 1 |
| Improved T-cell Receptor Diversity Estimates Associate with Survival and Respons [PMID:33177107] | Bortone DS, Woodcock MG, Parker JS, Vinc | Cancer Immunol Res | 2021 | 1 |
| Clocks, cancer, and chronochemotherapy. [PMID:33384351] | Sancar A, Van Gelder RN | Science | 2021 | 1 |
| Spatiotemporal profile of postsynaptic interactomes integrates components of com [PMID:28671696] | Li J, Zhang W, Yang H, Howrigan DP, Wilk | Nat Neurosci | 2017 | 1 |
| Core Concept: The Internet of Things and the explosion of interconnectivity. [PMID:27702874] | Ornes S | Proc Natl Acad Sci U S A | 2016 | 1 |
| Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and T [PMID:41833042] | ["Lyu G", "Li D"] | CNS & neurological disorders d | 2026 | 0 |
| Epigenetics and the gut-brain axis: Insights into DNA methylation, aging, and Al [PMID:41886887] | Kumar V, Shukla R, Gangani S, Joseph R, | The Journal of pharmacology an | 2026 | 0 |
| Effects of circadian rhythms on antimicrobial peptide concentrations in lactatin [PMID:41923233] | Liang ZL, Nii T, Sugino T, Isobe N | BMC veterinary research | 2026 | 0 |
| Circadian synchronization between diet and gut microbiota in modulating host's h [PMID:41914045] | ["Ma J", "Zhen Y", "Weng Y", "Lin J", "Z | Gut microbes | 2026 | 0 |
| Randomized controlled trial of resistance exercise and brain aging clocks. [PMID:41665740] | ["Gonzalez-Gomez R", "Demnitz N", "Coron | GeroScience | 2026 | 0 |
| Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses [PMID:41092646] | Lin L, Liang X, Xu Z, Li Y, Guo Z et al. | Biomaterials | 2026 | 0 |
| Pharmacological modulation of circadian rhythms in brain microvasculature. [PMID:41355044] | Yang Z, Kim M, Montgomery M, Lewandowski | J Cereb Blood Flow Metab | 2026 | 0 |
| The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mit [PMID:41486525] | Sica V, Sato T, Tsialtas I, Hernandez S, | J Biol Rhythms | 2026 | 0 |
| When Clocks Go Rogue: Circadian Rhythms and the Rise of Cancer. [PMID:41520235] | Robinson AS, Bennett S, Sato S | J Biol Rhythms | 2026 | 0 |
| Glycaemic, appetite and circadian benefits of a dairy-enriched diet with high-pr [PMID:41578008] | Tsameret S, Froy O, Matz Y, Landau Z, Tw | Diabetologia | 2026 | 0 |
| Lifestyle factors and DNA methylation-based aging clocks: cross-sectional and lo [PMID:41763011] | Shan J, Tay JH, Ye KX, Guo J, Cao L et a | J Prev Alzheimers Dis | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.90 · 2026-04-06
closed · Rounds: 4 · Score: 0.95 · 2026-04-06
Hypotheses and analyses mentioning Circadian clock / CLOCK-BMAL1 transcription in their description or question text
No additional research found