Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Choline: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Synapse Formation | promotes | process | 0.95 |
| Synapse Formation | activates | process | 0.90 |
| Phosphatide Synthesis | activates | pathway | 0.85 |
| Kennedy Cycle | involved_in | pathway | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Choline Transporter | associated_with | entity | 0.90 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Plasma ATN biomarkers across AD continuum in Chilean cohort | clinical | Alzheimer's disease | 0.950 | 0.00 | Chilean older adults (n=318) w | proposed | N/A |
| Electroacupuncture ST37 treatment for DSS-induced colitis in mice | validation | colitis | 0.950 | 0.00 | mice | proposed | N/A |
| Tau depletion effects on neuronal development in primary cultures | exploratory | 0.900 | 0.00 | primary rodent neuronal cultur | proposed | N/A | |
| Differential GWAS of schizophrenia vs PTSD | exploratory | schizophrenia, post-traumatic | 0.900 | 0.00 | human patients - European ance | proposed | N/A |
| Tau depletion effects on neuronal development in primary cultures | exploratory | 0.900 | 0.00 | primary rodent neuronal cultur | proposed | N/A | |
| Creation and validation of 3xAD-ChAT-Cre mouse model | validation | Alzheimer's disease | 0.900 | 0.00 | 3xAD-ChAT-Cre transgenic mice | proposed | N/A |
| HFD-induced cognitive dysfunction and neuroinflammation in mice | validation | diet-induced cognitive dysfunc | 0.900 | 0.00 | adult Swiss male mice | proposed | N/A |
| GTEx brain tissue expression analysis of MAPT/CRHR1 locus | exploratory | schizophrenia, post-traumatic | 0.850 | 0.00 | human brain tissue samples fro | proposed | N/A |
| α7nAChR agonist treatment rescues HFD-induced memory deficits | validation | diet-induced cognitive dysfunc | 0.850 | 0.00 | HFD-fed adult Swiss male mice | proposed | N/A |
| Microtubule domain analysis in adult axons | exploratory | 0.800 | 0.00 | adult rodent axons | proposed | N/A | |
| Tau depletion effects on microtubule domains in adult axons | exploratory | 0.800 | 0.00 | adult rodent neurons | proposed | N/A | |
| α7nAChR knockout mice show enhanced HFD sensitivity | validation | diet-induced cognitive dysfunc | 0.800 | 0.00 | Chrna7 knockout mice | proposed | N/A |
| Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Res | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Mixed Pathology Effects on Parkinson's Disease Progression and Treatme | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Clinical, Immunological, and Vesicular Markers in Sarcopenia and Presarcopenia. [PMID:40917056] | Shuliko LM, Svarovsky DA, Spirina LV, Og | Front Biosci (Landmark Ed) | 2025 | 1 |
| CD47-blocking antibody interferes with neutrophil extracellular traps formation [PMID:39951937] | Diao Y, Hao M, Xie M, Hu X, Tan R, Wang | J Neuroimmunol | 2025 | 1 |
| Asparagine Endopeptidase Inhibition Attenuates Tissue Plasminogen Activator-Indu [PMID:40116141] | Xie G, Jiang G, Huang L, Sun S, Li X, Wu | CNS Neurosci Ther | 2025 | 1 |
| Enhanced anticancer activity of nanoemulsified cardamom extract via modulation o [PMID:41658858] | ["Soltani T", "Karimian M", "Vaziri H", | Biochemistry and biophysics re | 2026 | 0 |
| Astrocytic α7-nicotinic acetylcholine receptors mediate pain information process [PMID:41453579] | Teng T, Yang S, Li J, Wang H, Wu F, He Y | Neurobiology of disease | 2026 | 0 |
| Signal-Level Determinants of Cognitive Decline With PPIs versus H2RAs: Transport [PMID:41663888] | Saihati HAA, Ahmed BY, Mosaad RM, El-Gar | Molecular nutrition & food res | 2026 | 0 |
| Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Ce [PMID:41928597] | Gholizadeh F, Hajiaghayi M, Rahbari N, C | Eur J Immunol | 2026 | 0 |
| Alpha 7 nicotinic acetylcholine receptor contributes to long-term cognitive reco [PMID:41270982] | Nguyen DT, Mendoza K, Hall C, Tan C, Cha | Experimental neurology | 2026 | 0 |
| Integrated transcriptomic, proteomic, and metabolomic analyses reveal molecular [PMID:41850064] | ["Wang H", "Liu Y", "Jiang K", "Yin J", | Poultry science | 2026 | 0 |
| Fragment merging design, synthesis, and biological evaluation of novel methyl Se [PMID:41785527] | ["Shaaban S", "Hawas S", "Elmaaty A", "B | Bioorganic & medicinal chemist | 2026 | 0 |
| Putative α7-selective ligands interact with α9-containing nicotinic acetylcholin [PMID:41890755] | Mobasher M, Hone AJ, Pilzecker M, Bozic | Frontiers in immunology | 2026 | 0 |
| Theranekron modulates extracellular matrix and apoptotic signaling pathways in c [PMID:41852375] | ["Kuccukturk S", "Duran T", "Vanli S", " | Cytotechnology | 2026 | 0 |
| Saliva liquid biopsy: MMP2, MMP9, and TIMP2 as potential diagnostic biomarkers i [PMID:41779471] | ["Cruz-Romero S", "Baldi\u00f3n A", "Taw | Journal of applied oral scienc | 2026 | 0 |
| Glomerular Transcriptome Analysis Reveals Endothelial Disturbances in Patients W [PMID:41659822] | ["Nelson-Taylor S", "Troost J", "Giannin | Kidney medicine | 2026 | 0 |
| Encapsulation of hydroxyurea in exosomes derived from adipose mesenchymal stem c [PMID:41702234] | ["Taheri Kangarshahi Z", "Ganji S", "Ash | Translational oncology | 2026 | 0 |
| Short-term exposure to a high-fat diet leads to neuroinflammation and impairs me [PMID:41565126] | Costa SO, Silva IM, Chaves WF, Esteves A | The Journal of nutritional bio | 2026 | 0 |
| Acetylcholine enhances HIF-1α signaling in pancreatic cancer cells under hypoxia [PMID:41608625] | Cho Y, Kim HG, Kang JH, Oh ET, Park HJ | International journal of biolo | 2026 | 0 |
| NSUN2 promoted tumor growth and metastatic via m [PMID:41794778] | ["Li R", "Jin D", "Shao S", "Guo J"] | Cell death & disease | 2026 | 0 |
| Membrane-Type 5 Matrix Metalloproteinase (MT5-MMP): Background and Proposed Role [PMID:40867559] | ["Jadhav D", "Knapinska A", "Wang H", "F | Biomolecules | 2025 | 0 |
| Central-peripheral neuroimmune dynamics in psychological stress and depression: [PMID:40610703] | Feng X, Jia M, Cai M, Zhu T, Hashimoto K | Molecular psychiatry | 2025 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Choline in their description or question text
Score: 0.730 · neurodegeneration · 2026-04-25
AD-risk trafficking defects in SORL1/BIN1/PICALM/retromer may generate parallel early outputs: amyloidogenic APP sorting
Score: 0.669 · neurodegeneration · 2026-04-02
## Mechanistic Overview Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Communication start
Score: 0.666 · neuroscience · 2026-04-07
## Mechanistic Overview Glymphatic-Cholinergic Tau Clearance Cascade starts from the claim that modulating MAPT within t
Score: 0.663 · translational neuroscience · 2026-04-16
**Molecular Mechanism and Rationale** Choline kinase alpha (CHKA) represents a critical regulatory enzyme in phospholip
Score: 0.630 · neurodegeneration · 2026-04-25
APOE4 may bias microglia toward complement-mediated pruning that disproportionately strips vulnerable long-range choline
Score: 0.629 · neurodegeneration · 2026-04-04
## Mechanistic Overview Selective Cholinergic Protection via APP Pathway Modulation starts from the claim that modulatin
Score: 0.620 · neurodegeneration · 2026-04-25
Early noradrenergic loss may shift inflammatory tone, amyloid clearance, and cholinergic resilience, thereby modulating
Score: 0.616 · neurodegeneration · 2026-04-16
## **Molecular Mechanism and Rationale** The nicotinamide adenine dinucleotide (NAD+) biosynthetic pathway represents a
Score: 0.610 · neurodegeneration · 2026-04-25
Loss of retrograde NGF-TrkA support could destabilize basal-forebrain cholinergic neurons early, lowering cortical acety
Score: 0.591 · neurodegeneration · 2026-04-16
**Molecular Mechanism and Rationale** The TREM2-C1Q competitive binding hypothesis centers on the intricate molecular i
Score: 0.551 · neuropharmacology · 2026-04-13
## Mechanistic Overview MFSD2A-Targeted Lysophosphatidylcholine-SPM Conjugates as CNS-Penetrant Pro-Resolving Prodrugs s
Score: 0.515 · unknown disease · 2026-04-26
Scheduled 3mg melatonin 30 minutes after donepezil administration optimizes MT1/AChE-inhibitor cross-talk for amyloid an
Score: 0.499 · methodology · 2026-04-12
## Mechanistic Overview Cholinergic Attention Modulation Hypothesis starts from the claim that modulating CHRNA7 within
Score: 0.450 · neurodegeneration · 2026-04-25
Soluble amyloid oligomers may injure cholinergic terminals via CHRNA7-linked calcium dysregulation, making cholinergic d
Score: 0.440 · neurodegeneration · 2026-04-25
Reactive astrocytes may degrade acetylcholine and destabilize cortical network states, secondarily creating conditions p