Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Ceramide Biosynthesis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
The enzymatic synthesis of ceramide, a sphingolipid signaling molecule, via three pathways: de novo synthesis from serine and palmitoyl-CoA (SPTLC1/2, CERS enzymes), sphingomyelin hydrolysis by sphingomyelinases (SMPD1-5), and the salvage pathway. Ceramide acts as a pro-apoptotic second messenger and its dysregulation is implicated in neurodegeneration, insulin resistance, and cancer.
Ontology: GO:0046513 · MESH:D054928
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| Name | Ceramide synthesis |
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Serine Palmitoyltransferase Inhibitors | inhibits | drug | 0.85 |
| Serine palmitoyltransferase inhibitors | inhibits | drug | 0.85 |
| Il10 Signaling | inhibits | pathway | 0.80 |
Hypotheses where this entity is a therapeutic target
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Ceramide Biosynthesis in their description or question text
No additional research found