gene

CREB3L1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CREB3L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

CREB3L1 Gene

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🧬 Gene Info

Gene Symbol	CREB3L1
Full Name	cAMP Responsive Element Binding Protein 3-Like 1
Chromosome	11p11.2
Protein Type	Transcription Factor
Function	CREB3L1 (OASIS) is a transcription factor with multiple roles
UniProt ID	Q7Z594
NCBI Gene ID	90993
Ensembl ID	ENSG00000127616
OMIM	612799
GeneCards	CREB3L1
Human Protein Atlas	CREB3L1
ER stress response	Activates UPR target genes under ER stress
Osteoblast differentiation	Essential for bone formation
Neuroprotection	Protects neurons from ER stress-induced cell death
Astrocyte function	Regulates astrocyte responses to injury
Associated Diseases	Hypochondroplasia (controversial), Cancers (multiple types), ER Stress-related disorders
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CREB3L1 — AlphaFold Q7Z594 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CREB3L1 Gene

gene · 540 words

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Pathway Diagram

graph TD
    CREB3L1["CREB3L1"]
    neurodegeneration["neurodegeneration"]
    CREB3L1 -->|"implicated_in"| neurodegeneration
    style CREB3L1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CREB3L1 in their description or question text

No additional research found