gene

CHMP1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHMP1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

CHMP1A is an ESCRT-III component critical for endosomal trafficking, autophagosome maturation, and lysosomal protein degradation. Mutations cause Charcot-Marie-Tooth disease and hereditary spastic paraplegia.

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🧬 Gene Info

Gene Symbol	CHMP1A
Full Name	Charged Multivesicular Body Protein 1A
Function	encodes Charged Multivesicular Body Protein 1A, also known as CHMP1A, a critical component of the ESCRT-III (Endosomal Sorting Complex Required for Transport-III) complex
Ensembl ID	ENSG00000130812
GeneCards	CHMP1A
Human Protein Atlas	CHMP1A
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CHMP1A — Charged Multivesicular Body Protein 1A

gene · 2678 words

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Pathway Diagram

graph TD
    CHMP1A["CHMP1A"]
    neurodegeneration["neurodegeneration"]
    CHMP1A -->|"implicated_in"| neurodegeneration
    style CHMP1A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHMP1A in their description or question text

No additional research found