Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHECK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CHEK1 encodes a serine/threonine-protein kinase essential for DNA damage checkpoint response and genomic stability in post-mitotic neurons. Implicated in Alzheimer's, Parkinson's, Huntington's disease, and ALS.
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| Gene Symbol | CHECK1 |
| Full Name | Cell Cycle Checkpoint Kinase 1 |
| Aliases | CHK1, Cdc2-like 1 (CLK1) |
| Chromosome | 11q24.2 |
| Protein Type | Kinase |
| Function | Upon genotoxic insult, ATR phosphorylates CHECK1 at multiple sites—most critically at Ser317 and Ser345—triggering a conformational change that enables kinase activity[@global2023]. |
| Primary Expression | Ubiquitous; highest in brain, testis, thymus |
| Molecular Weight | 54 kDa |
| Amino Acids | 433 aa |
| UniProt ID | O14757 |
| NCBI Gene ID | 1111 |
| GeneCards | CHECK1 |
| Human Protein Atlas | CHECK1 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, Huntington's disease, ALS |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CHECK1["CHECK1"]
neurodegeneration["neurodegeneration"]
CHECK1 -->|"implicated_in"| neurodegeneration
style CHECK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| genes-check1 | documents | wiki | 1.00 |
| genes-check1 | describes | wiki | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CHECK1 in their description or question text
No additional research found