gene

CHD8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHD8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Chromodomain Helicase DNA Binding Protein 8 - chromatin remodeler with roles in neurodevelopment, Wnt signaling, and neurodegeneration

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🧬 Gene Info

Gene Symbol	CHD8
Aliases	Chromodomain Helicase DNA Binding Protein 8
Chromosome	14q11.2
Protein Type	Gene
Function	is a critical ATP-dependent chromatin remodeling factor and transcriptional regulator.
Primary Expression	specific tissues
Molecular Weight	285 kDa
Amino Acids	563 aa
Pathways	Wnt
UniProt ID	Q9HCK8
NCBI Gene ID	57680
GeneCards	CHD8
Human Protein Atlas	CHD8
C-terminal region	Contains glutamine-rich regions and potential transcriptional activation domains.
Isoform 1 (canonical)	Full-length 2,563 aa protein
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CHD8 — AlphaFold Q9HCK8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CHD8 Gene

gene · 1830 words

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Pathway Diagram

graph TD
    CHD8["CHD8"]
    neurodegeneration["neurodegeneration"]
    CHD8 -->|"implicated_in"| neurodegeneration
    style CHD8 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHD8 in their description or question text

No additional research found