gene

CERNUNNOS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CERNUNNOS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Comprehensive information about CERNUNNOS (X-linked Magnesium-dependent Polymerase Adaptor Protein), including its role in DNA repair, neuronal survival, and neurodegenerative diseases including cerebellar ataxia and sensory neuropathy.

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🧬 Gene Info

Gene Symbol	CERNUNNOS
Full Name	X-linked Magnesium-dependent Polymerase Adaptor Protein
Aliases	Cernunnos protein
Chromosome	Xp22.12
Function	is a critical DNA repair protein essential for non-homologous end joining (NHEJ), the predominant pathway for repairing DNA double-strand breaks (DSBs) in eukaryotic cells.
Primary Expression	Cerebellum, Brainstem, Spinal Cord, Dorsal Root Ganglia
Molecular Weight	36 kDa
Amino Acids	330 aa
Exons	7
UniProt ID	Q9Y2V71
NCBI Gene ID	124454
Ensembl ID	ENSG00000196433
OMIM	300515
GeneCards	CERNUNNOS
Human Protein Atlas	CERNUNNOS
Associated Diseases	Cerebellar Ataxia, Sensory Neuropathy, Neurodegeneration
Databases	GeneCards HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CERNUNNOS["CERNUNNOS"]
    neurodegeneration["neurodegeneration"]
    CERNUNNOS -->|"implicated_in"| neurodegeneration
    style CERNUNNOS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CERNUNNOS in their description or question text

No additional research found