Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CD79A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CD79A |
| Full Name | CD79a Molecule |
| Chromosome | 19q13.2 |
| Function | CD79A (Igα) is a type I transmembrane protein belonging to the immunoglobulin superfamily |
| UniProt ID | P11912 |
| NCBI Gene ID | 973 |
| Ensembl ID | ENSG00000105369 |
| OMIM | 112510 |
| GeneCards | CD79A |
| Human Protein Atlas | CD79A |
| Tyrosine Phosphorylation | Upon antigen binding, ITAM tyrosines are phosphorylated by Src family kinases |
| Syk Recruitment | Phosphorylated ITAMs recruit and activate Syk kinase |
| Downstream Cascades | Activates BTK, PLCγ2, and downstream effectors |
| Calcium Flux | Leads to intracellular calcium release and NFAT activation |
| Pro-B/Pre-B Cells | BCR expression required for progression |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CD79A["CD79A"]
neurodegeneration["neurodegeneration"]
CD79A -->|"implicated_in"| neurodegeneration
style CD79A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CD79A in their description or question text
No additional research found