Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CATHEPSINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CATHEPSINE |
| Full Name | Cathepsin E |
| Chromosome | 1q31.1 |
| Protein Type | Protein |
| Function | is an aspartic protease predominantly expressed in immune cells and the gastrointestinal tract. |
| Primary Expression | immune cells and the gastrointestinal tract |
| Amino Acids | 437 aa |
| UniProt ID | Search UniProt |
| GeneCards | CATHEPSINE |
| Human Protein Atlas | CATHEPSINE |
| Cathepsin D | aspartic protease with overlapping substrate specificity |
| Cathepsin B | cysteine protease; complementary lysosomal degradation pathway |
| Amyloid Precursor Protein (APP) | substrate for cathepsin E processing |
| Alpha-synuclein | protein whose clearance involves cathepsin E |
| Lysosomal dysfunction | central to cathepsin E pathophysiology |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CATHEPSINE["CATHEPSINE"]
neurodegeneration["neurodegeneration"]
CATHEPSINE -->|"implicated_in"| neurodegeneration
style CATHEPSINE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| No outgoing edges | |||
| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CATHEPSINE in their description or question text
No additional research found