Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Beta-secretase / amyloidogenic pathway: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| BACE1 | participates_in | gene | 0.39 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Palmitoylation-Targeted BACE1 Trafficking Disruptors | 0.693 | neurodegeneration | Lipid raft composition changes in synapt |
| Selective Cholinergic Protection via APP Pathway Modulation | 0.629 | neurodegeneration | Clinical Trial Landscaping for Alzheimer |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.852
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Plasma ATN biomarkers across AD continuum in Chilean cohort | clinical | Alzheimer's disease | 0.950 | 0.00 | Chilean older adults (n=318) w | proposed | N/A |
| Adoptive transfer of TCRAβ-Tregs in AD mouse model | validation | Alzheimer's disease | 0.900 | 0.00 | transgenic mice expressing chi | proposed | N/A |
| ER-Golgi Secretory Pathway Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217] | Chang CH, Lin CH, Lane HY | Int J Mol Sci | 2021 | 1 |
| Cataract Aggravates Alzheimer-Like Pathologies and Cognitive Deficits in an APP/ [PMID:40580389] | Geng Z, Yu ZY, Tan J, Wang XY, Zeng GH e | Neurosci Bull | 2026 | 0 |
| HOPS disruption impairs APP trafficking and processing, promoting exosomal secre [PMID:41525887] | Draper D, George AE, Veenendaal T, van D | Neurobiol Dis | 2026 | 0 |
| Amyloid-β fibrils accumulated in preeclamptic placentas suppress cytotrophoblast [PMID:41558820] | Nishioka K, Ikezaki M, Iwahashi N, Araka | Life Sci Alliance | 2026 | 0 |
| TREM2 expression level is critical for microglial state, metabolic capacity and [PMID:41580393] | Feiten AF, Dahm K, Schlepckow K, van Len | Nat Commun | 2026 | 0 |
| APP-C31 pathology as a target in neurodegenerative diseases. [PMID:41639863] | Yip KC, Ho WF, Liu Y, Dawe GS | J Biomed Sci | 2026 | 0 |
| An anti-inflammatory neuroenhancer mitigates amyloid-β pathology to improve Alzh [PMID:41696149] | Fang W, Zhao J, Li L, Wang Y, Xu ZP et a | Mater Today Bio | 2026 | 0 |
| Decoding Alzheimer's disease through down syndrome: insights from a genetically [PMID:41709686] | Russell JK, Schlachetzki Z, Rafii MS | Curr Opin Neurol | 2026 | 0 |
| Apps for people with vision impairment: an international review of practitioner [PMID:41734772] | Gothwal VK, Miller A, Boon MY, Subramani | Clin Exp Optom | 2026 | 0 |
| Impaired TGFβ Signaling in Plaque-Associated Microglia. [PMID:41750318] | Krzyzan O, Kuhla A, Spittau B, Vidovic N | Biomolecules | 2026 | 0 |
| APP as an innate injury-response molecule. [PMID:41864298] | Olmsted ZT, Sofroniew MV | Neurobiol Dis | 2026 | 0 |
| Intranasal administration of neural stem cell-derived extracellular vesicles pre [PMID:41923110] | Natale Francesca; Dellaria Alice; Nifo S | Alzheimer's research & the | 2026 | 0 |
| Salvianolic acid a inhibits neuroinflammation and ameliorates Alzheimer's diseas [PMID:41930874] | Xiao S, Han Y, Yan J, Wu L, Lin H et al. | Int Immunopharmacol | 2026 | 0 |
| CRISPR-Cas9 and next-generation gene editing strategies for therapeutic interven [PMID:41931258] | Khan MS, Zafar I, Jamal A, Bahwerth FS, | Acta Neurol Belg | 2026 | 0 |
| Akkermansia muciniphila reduces neuroinflammation and Aβ deposition via tryptoph [PMID:41715194] | Wang B, Pan M, Yang L, Xu J, Ye C, Li Y, | Alzheimer's research & therapy | 2026 | 0 |
| Alzheimer's disease basics: we all should know. [PMID:40639927] | Das S | Neurological research | 2026 | 0 |
| Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation. [PMID:41376284] | Xie XY, Wang L, Xie SQ, Zhou GF, Wen QX, | Autophagy | 2026 | 0 |
| Demethyleneberberine attenuates combined cognitive and metabolic dysfunctions in [PMID:41482106] | Kaur A, Singh S, Singh M, Silakari P, Ma | Experimental neurology | 2026 | 0 |
| AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategie [PMID:41268687] | Chen J, Liu B, Yao X, Yang X, Sun J et a | CNS Neurosci Ther | 2025 | 0 |
| AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategie [PMID:41268687] | Chen J, Liu B, Yao X, Yang X, Sun J, Yi | CNS neuroscience & therapeutic | 2025 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 5 · Score: 0.93 · 2026-04-11
Hypotheses and analyses mentioning Beta-secretase / amyloidogenic pathway in their description or question text
No additional research found