Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Balance: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Hair Cells | involved_in | cell_type | 0.95 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| MAPK pathway inhibition by QTJD through butyrate mechanism | exploratory | Mycoplasma pneumoniae pneumoni | 0.900 | 0.00 | Mouse macrophages | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3B [PMID:36692217] | Yang C, Wang Z, Kang Y, Yi Q, Wang T, Ba | Autophagy | 2023 | 3 |
| Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal [PMID:41498748] | Unknown | The Journal of cell biology | 2026 | 0 |
| Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal [PMID:41498748] | Byrd, Marmorale, Marcinowski, Dykstra, A | The Journal of cell biology | 2026 | 0 |
| The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213] | Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei | Neuron | 2026 | 0 |
| Role of TREM2 in neuroinflammation. [PMID:41213496] | Abdulkhaliq AA, Alasiri G, Almoghrabi Y, | Exp Neurol | 2026 | 0 |
| Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophag [PMID:41355531] | Wang J, Wang S, Ren L, Liu X, Zhang L et | Adv Sci (Weinh) | 2026 | 0 |
| Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fib [PMID:41431138] | Pan W, Yong Y, Li Y, Shi G, Zhang M et a | Adv Sci (Weinh) | 2026 | 0 |
| Synergistic potential of TREM2 agonists and exercise training in Alzheimer's dis [PMID:41494649] | Zhang J, St Pierre Schneider B, Muguerza | Am J Physiol Endocrinol Metab | 2026 | 0 |
| Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are in [PMID:41513633] | He S, Mittra N, Bao H, Bhattacharjee A, | Nat Commun | 2026 | 0 |
| Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952] | Li X, Tang X, Zeng J, Duan L, Hou Z et a | Cell | 2026 | 0 |
| TREM2 expression level is critical for microglial state, metabolic capacity and [PMID:41580393] | Feiten AF, Dahm K, Schlepckow K, van Len | Nat Commun | 2026 | 0 |
| Neuregulin1-ErbB4 Signaling Involved in Acupuncture Promoting Myelin Regeneratio [PMID:41801841] | Shen J, Zhao Y, Jiang C, Huang Y, Wang L | J Vis Exp | 2026 | 0 |
| TREM2 in neurodegeneration and diseases. [PMID:41792456] | ["Abdulkhaliq A", "Alasiri G", "Kim B", | Molecular psychiatry | 2026 | 0 |
| A quantitative DOPA decarboxylase biomarker for diagnosis in Lewy body disorders [PMID:41699128] | ["Bolsewig K", "Bellomo G", "Hok-A-Hin Y | Nature medicine | 2026 | 0 |
| Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721] | Aranda-Abreu GE, Rojas-Durán F, Hernánde | Neurology international | 2026 | 0 |
| The microglial TREM2 receptor programs hippocampal development in a mouse model [PMID:41887542] | Ahmed S, Bowers C, Munoz-Martin J, Jamwa | Brain, behavior, and immunity | 2026 | 0 |
| Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842] | Alhusaini M, Mussa BM, Ilce BY, Alhaj H, | Frontiers in aging neuroscienc | 2026 | 0 |
| Viral and non-viral cellular therapies for neurodegeneration. [PMID:41585268] | ["Srivastav Jyotsna", "Sharma Sachin"] | Frontiers in medicine | 2025 | 0 |
| Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by [PMID:39881147] | ["Bolsewig K", "Willemse E", "S\u00e1nch | Nature communications | 2025 | 0 |
| Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy [PMID:38056575] | Wu S, Zhou Y, Liang J | Free Radic Biol Med | 2024 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Balance in their description or question text
Score: 0.520 · neurodegeneration · 2026-04-22
## Mechanistic Overview Inhibitory Neuron Subtype Loss: Excitation/Inhibition Imbalance Hypothesis starts from the claim
Score: 0.520 · neurodegeneration · 2026-04-22
## Mechanistic Overview Dysregulated microglial glycolysis via HIF1α activation shifts the balance from neuroprotective
Score: 0.481 · protein folding · 2026-04-22
## Mechanistic Overview Isoform-Selective Hsp70 Targeting Overcomes Stoichiometric Imbalance in Advanced Pathology start
Score: 0.473 · neurodegeneration · 2026-04-21
## Mechanistic Overview Cerebral VSMC foam cells induce pericyte detachment via PDGF-BB/VEGF imbalance, impairing neurov
Score: 0.335 · neurodegeneration · 2026-04-26
A longitudinal biomarker panel centered on K48/K63 ubiquitin chain balance can distinguish harmful mechanisms from prote