entity

Anti-Inflammatory

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Anti-Inflammatory: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections
4Hypotheses
0Analyses
0Outgoing
4Incoming
4Experiments
0Debates

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Wiki Pages (3)

Knowledge base pages for this entity

Anti-Inflammatory Therapy for Neurodegeneration

therapeutic · 1748 words

YKL-40 Anti-Inflammatory Cycling

idea · 1692 words

YKL-40-Targeted Anti-Inflammatory Therapy for Neurodegeneration

idea · 642 words

Outgoing (0)

TargetRelationTypeStr
No outgoing edges

Incoming (4)

SourceRelationTypeStr
Gallic Acidmediatescompound0.90
BDNFinvolved_inprotein0.80
HO-1promotesgene0.80
Kadsura coccineaassociated_withdrug0.65

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Hypothesis 2: GPNMB-CD44 Axis as Anti-inflammatory Pathway 0.772 neurodegeneration View
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A 0.669 neurodegeneration What are the mechanisms by which gut mic
Anti-inflammatory microglial reprogramming via cystatin-C/TR 0.640 neurodegeneration Does the cancer-cystatin-C-TREM2 pathway
A lower-dose 50-100 mg/day glial anti-inflammatory effect ma 0.480 neurodegeneration -

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (4)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
Electroacupuncture ST37 treatment for DSS-induced colitis in mice validation colitis 0.950 0.00 mice proposed N/A
HFD-induced cognitive dysfunction and neuroinflammation in mice validation diet-induced cognitive dysfunc 0.900 0.00 adult Swiss male mice proposed N/A
α7nAChR agonist treatment rescues HFD-induced memory deficits validation diet-induced cognitive dysfunc 0.850 0.00 HFD-fed adult Swiss male mice proposed N/A
α7nAChR knockout mice show enhanced HFD sensitivity validation diet-induced cognitive dysfunc 0.800 0.00 Chrna7 knockout mice proposed N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Astrocytic α7-nicotinic acetylcholine receptors mediate pain information process [PMID:41453579] Teng T, Yang S, Li J, Wang H, Wu F, He Y Neurobiology of disease 2026 0
Signal-Level Determinants of Cognitive Decline With PPIs versus H2RAs: Transport [PMID:41663888] Saihati HAA, Ahmed BY, Mosaad RM, El-Gar Molecular nutrition & food res 2026 0
The temporal and stimuli-specific effects of LPS and IFNγ on microglial activati [PMID:41695273] Heiss CN, Naylor AS, Pesämaa I, Meshi A, Front Aging Neurosci 2026 0
Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Ce [PMID:41928597] Gholizadeh F, Hajiaghayi M, Rahbari N, C Eur J Immunol 2026 0
Alpha 7 nicotinic acetylcholine receptor contributes to long-term cognitive reco [PMID:41270982] Nguyen DT, Mendoza K, Hall C, Tan C, Cha Experimental neurology 2026 0
Putative α7-selective ligands interact with α9-containing nicotinic acetylcholin [PMID:41890755] Mobasher M, Hone AJ, Pilzecker M, Bozic Frontiers in immunology 2026 0
Short-term exposure to a high-fat diet leads to neuroinflammation and impairs me [PMID:41565126] Costa SO, Silva IM, Chaves WF, Esteves A The Journal of nutritional bio 2026 0
Acetylcholine enhances HIF-1α signaling in pancreatic cancer cells under hypoxia [PMID:41608625] Cho Y, Kim HG, Kang JH, Oh ET, Park HJ International journal of biolo 2026 0
Central-peripheral neuroimmune dynamics in psychological stress and depression: [PMID:40610703] Feng X, Jia M, Cai M, Zhu T, Hashimoto K Molecular psychiatry 2025 0
The ATP-mediated cytokine release by macrophages is down-modulated by unconventi [PMID:41221292] Wolf PMK, Hanke D, Singh VK, Keller HL, Frontiers in immunology 2025 0
Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α [PMID:38504011] Xia XM, Duan Y, Wang YP, Han RX, Dong YF Acta Pharmacol Sin 2024 0
Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-o [PMID:38944290] ["Yang Y", "Eguchi A", "Mori C", "Hashim Journal of affective disorders 2024 0
Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α [PMID:38504011] Xia XM, Duan Y, Wang YP, Han RX, Dong YF Acta pharmacologica Sinica 2024 0
CD44 connects autophagy decline and ageing in the vascular endothelium. [PMID:37684253] Unknown Nat Commun 2023 0
A role of gut-microbiota-brain axis via subdiaphragmatic vagus nerve in depressi [PMID:36191806] ["Yang Y", "Eguchi A", "Wan X", "Chang L Progress in neuro-psychopharma 2023 0
The membrane receptor CD44: novel insights into metabolism. [PMID:35249813] Unknown Trends Endocrinol Metab 2022 0
Unilateral Cervical Vagotomy Modulates Immune Cell Profiles and the Response to [PMID:36077246] Newell-Rogers MK, Duong A, Nazarali R, T International journal of molec 2022 0
CD44: A Multifunctional Mediator of Cancer Progression. [PMID:34944493] Unknown Biomolecules 2021 0
Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425] Lieberwirth JK, Joset P, Heinze A, Hents European journal of human gene 2021 0
Vagus Nerve Stimulation and the Cardiovascular System. [PMID:31109966] Capilupi MJ, Kerath SM, Becker LB Cold Spring Harbor perspective 2020 0

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning Anti-Inflammatory in their description or question text

No additional research found