gene

ATXN17

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATXN17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for ATXN17

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🧬 Gene Info

Gene Symbol	ATXN17
Full Name	Ataxin-17
Chromosome	6p21.1
Protein Type	Transcription Factor
Function	While ATXN17's specific biological functions are not well-characterized, it is understood to be part of the broader SCA17 genomic region:
Primary Expression	all tissues - High expression in: - Cerebellum (Purkinje cells) - Cerebral cortex (neurons) - Basal ganglia - [Hippoc
UniProt ID	Q9UH73
NCBI Gene ID	80022
Ensembl ID	ENSG00000204237
OMIM	607786
GeneCards	ATXN17
Human Protein Atlas	ATXN17
General transcription factor	TBP is a core component of the transcription factor IID (TFIID) complex
DNA binding	Binds to the TATA box promoter element
Gene expression	Central role in transcription initiation for RNA polymerase II
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ATXN17 — AlphaFold Q9UH73 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ATXN17

gene · 568 words

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Pathway Diagram

graph TD
    A["ATXN17
(Ataxin-17)"]
    B["Protein Misfolding"]
    C["Polyglutamine Expansion"]
    D["Neuronal Dysfunction"]
    E["Synaptic Transmission
Defects"]
    F["Mitochondrial
Dysfunction"]
    G["Oxidative Stress"]
    H["Calcium Homeostasis
Disruption"]
    I["Neuroinflammation"]
    J["Apoptosis"]
    K["Neurodegeneration"]
    L["Spinocerebellar
Ataxia"]
    M["HSP70
(Heat Shock Proteins)"]
    N["Autophagy
Machinery"]

    A -->|"causes"| C
    C -->|"leads to"| B
    B -->|"triggers"| D
    D -->|"impairs"| E
    D -->|"disrupts"| F
    F -->|"increases"| G
    G -->|"disturbs"| H
    H -->|"activates"| I
    I -->|"promotes"| J
    J -->|"results in"| K
    K -->|"manifests as"| L
    M -->|"attempts to refold"| B
    N -->|"clears"| B

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#ffffff
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#ffffff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#ffffff
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#ffffff

    class A central
    class M,N protective
    class B,C,D,E,F,G,H,I,J,K pathological
    class L disease

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ATXN17 in their description or question text

No additional research found