Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATP13A4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Gene Symbol | ATPase Cation Transporting Member 4 |
| Aliases | ATP13A4 |
| Chromosome | 3q29 |
| Protein Type | P5B-type ATPase, cation transporter |
| Function | is a member of the P5B-type ATPase family, a group of cation transport proteins that play critical roles in cellular homeostasis and have been increasingly implicated in neurodegenerative diseases. |
| Primary Expression | neural tissue and has been linked to various aspects of neuronal health and disease |
| Subcellular Localization | endolysosomal compartments, where they regulate cation transport across membrane boundaries. This subfamily includes fiv |
| Amino Acids | 924 aa |
| UniProt ID | Q9H0M0 |
| NCBI Gene ID | 85365 |
| Ensembl ID | ENSG00000119661 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ATP13A4["ATP13A4
(P-type ATPase)"]
ER["Endoplasmic Reticulum"]
Ca_homeostasis["Calcium Homeostasis"]
ER_stress["ER Stress"]
UPR["Unfolded Protein Response"]
ATP_hydrolysis["ATP Hydrolysis"]
Ca_transport["Ca2+ Transport"]
mitochondria["Mitochondrial Function"]
oxidative_stress["Oxidative Stress"]
protein_misfolding["Protein Misfolding"]
autophagy["Autophagy"]
apoptosis["Apoptosis"]
neurodegeneration["Neurodegeneration"]
neuron_death["Neuronal Death"]
synaptic_dysfunction["Synaptic Dysfunction"]
ATP13A4 -->|"localizes to"| ER
ATP13A4 -->|"hydrolyzes"| ATP_hydrolysis
ATP_hydrolysis -->|"drives"| Ca_transport
Ca_transport -->|"maintains"| Ca_homeostasis
Ca_homeostasis -->|"prevents"| ER_stress
ER_stress -->|"activates"| UPR
ER_stress -->|"promotes"| protein_misfolding
protein_misfolding -->|"triggers"| autophagy
ER_stress -->|"causes"| oxidative_stress
oxidative_stress -->|"damages"| mitochondria
mitochondria -->|"dysfunction leads to"| apoptosis
UPR -->|"chronic activation causes"| apoptosis
apoptosis -->|"results in"| neuron_death
neuron_death -->|"contributes to"| neurodegeneration
Ca_homeostasis -->|"disruption affects"| synaptic_dysfunction
synaptic_dysfunction -->|"leads to"| neurodegeneration
classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#fff
class ATP13A4 central
class Ca_homeostasis,autophagy protective
class ER_stress,oxidative_stress,protein_misfolding,apoptosis,neuron_death pathological
class UPR,ATP_hydrolysis,Ca_transport regulatory
class neurodegeneration,synaptic_dysfunction disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ATP13A4 in their description or question text
No additional research found