Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATG9L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ATG9L1 |
| Chromosome | 4q21.1 |
| Protein Type | Gene |
| Function | is a human gene encoding a multi-pass transmembrane protein that plays a crucial role in autophagosome formation. |
| Amino Acids | 736 aa |
| UniProt ID | Q6ZNG7 |
| NCBI Gene ID | 137886 |
| Ensembl ID | ENSG00000155189 |
| GeneCards | ATG9L1 |
| Human Protein Atlas | ATG9L1 |
| Alternative Names | ATG9L, ATG9A-like protein |
| Transcript Length | ~3.5 kb |
| N-terminal Cytosolic Domain | Contains binding motifs for autophagy proteins |
| Transmembrane Regions | 6-7 transmembrane segments forming pores |
| C-terminal Cytosolic Domain | Contains regulatory motifs |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ATG9L1["ATG9L1"]
autophagy_init["Autophagy initiation"]
vesicle_traffic["Vesicle trafficking"]
atg9_complex["ATG9 complex formation"]
phagophore["Phagophore assembly"]
autophagosome["Autophagosome formation"]
protein_agg["Protein aggregation"]
alpha_syn["alpha-synuclein accumulation"]
tau_agg["Tau aggregation"]
mito_dysfunction["Mitochondrial dysfunction"]
neuronal_death["Neuronal cell death"]
parkinsons["Parkinson's disease"]
alzheimers["Alzheimer's disease"]
neurodegeneration["Neurodegeneration"]
ATG9L1 -->|"regulates"| autophagy_init
ATG9L1 -->|"mediates"| vesicle_traffic
ATG9L1 -->|"forms"| atg9_complex
atg9_complex -->|"initiates"| phagophore
phagophore -->|"develops into"| autophagosome
autophagosome -->|"degrades"| protein_agg
autophagosome -->|"clears"| alpha_syn
autophagosome -->|"removes"| tau_agg
autophagosome -->|"eliminates"| mito_dysfunction
protein_agg -->|"promotes"| neuronal_death
alpha_syn -->|"causes"| parkinsons
tau_agg -->|"leads to"| alzheimers
neuronal_death -->|"results in"| neurodegeneration
parkinsons -->|"contributes to"| neurodegeneration
alzheimers -->|"contributes to"| neurodegeneration
classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#fff
class ATG9L1 central
class autophagy_init,vesicle_traffic,atg9_complex,phagophore,autophagosome protective
class protein_agg,alpha_syn,tau_agg,mito_dysfunction,neuronal_death pathological
class parkinsons,alzheimers,neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ATG9L1 in their description or question text
No additional research found