gene

ATG9B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG9B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for ATG9B

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🧬 Gene Info

Gene Symbol	ATG9B
Aliases	EPT1, FLJ00134, SEO1
Chromosome	7q36.1
Protein Family	ATG9 family
Function	Atg9B plays an important role in the study of neurodegenerative diseases
Primary Expression	various tissues with particular abundance in the brain, liver, and endocrine tissues
Molecular Weight	77 kDa
UniProt ID	Q7Z6Z8
NCBI Gene ID	285525
Ensembl ID	ENSG00000154997
GeneCards	ATG9B
Human Protein Atlas	ATG9B
Six transmembrane helices	Spanning the membrane multiple times
N-terminal cytosolic domain	Contains linear sorting motifs
C-terminal cytosolic domain	Functions in protein-protein interactions
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ATG9B — AlphaFold Q7Z6Z8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ATG9B

gene · 800 words

→

ATG9B Protein

protein · 577 words

→

Pathway Diagram

graph TD
    ATG9B["ATG9B"]
    autophagy_initiation["Autophagy Initiation"]
    ULK1["ULK1 Complex"]
    PI3K_complex["PI3K Complex"]
    autophagosome_formation["Autophagosome Formation"]
    ATG16L1["ATG16L1"]
    LC3_lipidation["LC3 Lipidation"]
    cargo_recognition["Cargo Recognition"]
    protein_aggregates["Protein Aggregates"]
    mitochondria_clearance["Mitochondrial Clearance"]
    lysosome_fusion["Lysosome Fusion"]
    neurodegeneration["Neurodegeneration"]
    alpha_synuclein["alpha-Synuclein Aggregates"]
    tau_tangles["Tau Tangles"]
    oxidative_stress["Oxidative Stress"]
    neuronal_death["Neuronal Death"]

    ATG9B -->|"facilitates"| autophagy_initiation
    autophagy_initiation -->|"activates"| ULK1
    ULK1 -->|"activates"| PI3K_complex
    PI3K_complex -->|"promotes"| autophagosome_formation
    ATG9B -->|"essential for"| autophagosome_formation
    autophagosome_formation -->|"recruits"| ATG16L1
    ATG16L1 -->|"enables"| LC3_lipidation
    LC3_lipidation -->|"mediates"| cargo_recognition
    cargo_recognition -->|"targets"| protein_aggregates
    cargo_recognition -->|"promotes"| mitochondria_clearance
    autophagosome_formation -->|"leads to"| lysosome_fusion
    protein_aggregates -->|"accumulate as"| alpha_synuclein
    protein_aggregates -->|"accumulate as"| tau_tangles
    alpha_synuclein -->|"contributes to"| neurodegeneration
    tau_tangles -->|"contributes to"| neurodegeneration
    mitochondria_clearance -->|"prevents"| oxidative_stress
    oxidative_stress -->|"promotes"| neuronal_death
    neuronal_death -->|"results in"| neurodegeneration

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#ffffff
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#ffffff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#ffffff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#ffffff
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#ffffff

    class ATG9B central
    class autophagy_initiation,autophagosome_formation,mitochondria_clearance,cargo_recognition,LC3_lipidation protective
    class protein_aggregates,alpha_synuclein,tau_tangles,oxidative_stress,neuronal_death pathological
    class ULK1,PI3K_complex,ATG16L1,lysosome_fusion regulatory
    class neurodegeneration disease

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATG9B in their description or question text

No additional research found